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505227 (-)-Cytisine - CAS 485-35-8 - Calbiochem

(-)-Cytisine - CAS 485-35-8 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: nAChR Agonist, (-)-Cytisine, Nicotinic Acetylcholine Receptor Agonist, (-)-Cytisine, Baptitoxine, Sophorine

Primary Target: nAChR
505227
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #Empirical Formula
485-35-8C₁₁H₁₄N₂O

Products

KatalógusszámCsomagolás Menny./csomag
5.05227.0001 Üvegpalack 10 mg
Description
OverviewA potent agonist selective for neuronal nAChRs (Ki = 2, 5890, 480, 329, and 492 nM at α4β2, α7, α3β4, α6/α4β4, α1β1γδ, respectively). Clinically used as a smoking cessation medicine and often used in addiction studies.
Catalogue Number505227
Brand Family Calbiochem®
SynonymsnAChR Agonist, (-)-Cytisine, Nicotinic Acetylcholine Receptor Agonist, (-)-Cytisine, Baptitoxine, Sophorine
References
ReferencesChen, Y., et al., 2012. Br J Pharmacol. 165, 1006.
West, R., 2011, N. Engl. J. Med. 365, 1193.
Happe, K., et al., 1994. Neurosci. 62, 929.
Reavill, C. et al., 1990. Neuropharmacol. 29, 619.
Product Information
CAS number485-35-8
FormPale yellow solid
Hill FormulaC₁₁H₁₄N₂O
Chemical formulaC₁₁H₁₄N₂O
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetnAChR
Primary Target K<sub>i</sub>2, 5890, 480, 329, and 492 nM at &alpha
Purity≥99% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 35-36/37/38

Causes severe burns.
Irritating to eyes, respiratory system and skin.
S PhraseS: 22-26-28.1-36/37/39-46-63

Do not breathe dust.
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
After contact with skin, wash immediately with plenty of water.
Wear suitable protective clothing, gloves and eye/face protection.
If swallowed, seek medical advice immediately and show this container or label.
In case of accident by inhalation: remove casualty to fresh air and keep at rest.
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
5.05227.0001 04055977263503

Documentation

(-)-Cytisine - CAS 485-35-8 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

References

Hivatkozások áttekintése
Chen, Y., et al., 2012. Br J Pharmacol. 165, 1006.
West, R., 2011, N. Engl. J. Med. 365, 1193.
Happe, K., et al., 1994. Neurosci. 62, 929.
Reavill, C. et al., 1990. Neuropharmacol. 29, 619.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision26-July-2013 JSW
SynonymsnAChR Agonist, (-)-Cytisine, Nicotinic Acetylcholine Receptor Agonist, (-)-Cytisine, Baptitoxine, Sophorine
DescriptionA potent agonist selective for neuronal nAChRs (Ki = 2, 5890, 480, 329, and 492 nM at α4β2, α7, α3β4, α6/α4β4, α1β1γδ, respectively). Clinically used as a smoking cessation medicine and often used in addiction studies.
FormPale yellow solid
CAS number485-35-8
Chemical formulaC₁₁H₁₄N₂O
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityH₂O (100 mM)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.
Toxicity Toxic
ReferencesChen, Y., et al., 2012. Br J Pharmacol. 165, 1006.
West, R., 2011, N. Engl. J. Med. 365, 1193.
Happe, K., et al., 1994. Neurosci. 62, 929.
Reavill, C. et al., 1990. Neuropharmacol. 29, 619.