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505875 (+)-Bicuculline - CAS 485-49-4 - Calbiochem

(+)-Bicuculline - CAS 485-49-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: GABAA Receptor Antagonist, Bicuculline

Primary Target: GABAA
505875
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Áttekintés

Replacement Information

Kulcsspecifikációk táblázata

CAS #Empirical Formula
485-49-4C₂₀H₁₇NO₆

Products

KatalógusszámCsomagolás Menny./csomag
5.05875.0001 Üvegpalack 50 mg
Description
OverviewA potent allosteric antagonist of vertebrate GABAA receptors. Blocks GABAA-induced chloride currents in cultured neurons (IC50 = 740 nM). Shown to increase blood pressure in spontaneously hypertensive rats and cause convulsion in experimental animals. Also, increases the amplitude of spontaneous colonic contractions.
Catalogue Number505875
Brand Family Calbiochem®
SynonymsGABAA Receptor Antagonist, Bicuculline
References
ReferencesUeno, S., et al. 1997. J. Neurosci. 17, 625.
Uchida, I., et al. 1996. Eur. J. Pharmacol. 307, 89.
Minocha, A., and Galligan, J.J. 1993. Eur. J. Pharmacol. 230, 187.
Robert K.A., et al. 1993. Cardiovasc. Pharmacol. 21, 156.
Product Information
CAS number485-49-4
FormPale yellow solid
Hill FormulaC₂₀H₁₇NO₆
Chemical formulaC₂₀H₁₇NO₆
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetGABAA
Primary Target IC<sub>50</sub>740 Nm
Purity≥99% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 23-24-28-46

Toxic by inhalation.
Toxic in contact with skin.
Very toxic if swallowed.
May cause heritable genetic damage.
S PhraseS: 22-28.1-36/37/39

Do not breathe dust.
After contact with skin, wash immediately with plenty of water.
Wear suitable protective clothing, gloves and eye/face protection.
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Katalógusszám GTIN
5.05875.0001 04055977263114

Documentation

(+)-Bicuculline - CAS 485-49-4 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

(+)-Bicuculline - CAS 485-49-4 - Calbiochem Certificates of Analysis

TitleLot Number
505875

References

Hivatkozások áttekintése
Ueno, S., et al. 1997. J. Neurosci. 17, 625.
Uchida, I., et al. 1996. Eur. J. Pharmacol. 307, 89.
Minocha, A., and Galligan, J.J. 1993. Eur. J. Pharmacol. 230, 187.
Robert K.A., et al. 1993. Cardiovasc. Pharmacol. 21, 156.

Brochure

Title
New Products Flyer- Feb 2014 - Vol 1
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision20-September-2013 JSW
SynonymsGABAA Receptor Antagonist, Bicuculline
DescriptionA potent allosteric antagonist of vertebrate GABAA receptors. Blocks GABAA-induced chloride currents in cultured neurons (IC50 = 740 nM). Shown to increase blood pressure in spontaneously hypertensive rats and cause convulsion in experimental animals. Also, increases the amplitude of spontaneous colonic contractions.
FormPale yellow solid
CAS number485-49-4
Chemical formulaC₂₀H₁₇NO₆
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Toxic
ReferencesUeno, S., et al. 1997. J. Neurosci. 17, 625.
Uchida, I., et al. 1996. Eur. J. Pharmacol. 307, 89.
Minocha, A., and Galligan, J.J. 1993. Eur. J. Pharmacol. 230, 187.
Robert K.A., et al. 1993. Cardiovasc. Pharmacol. 21, 156.