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344300
Sigma-AldrichsFRP-1 Inhibitor - CAS 915754-88-0 - Calbiochem
The sFRP-1 Inhibitor, also referenced under CAS 915754-88-0, controls the biological activity of sFRP-1. This small molecule/inhibitor is primarily used for Activators/Inducers applications.
More>>The sFRP-1 Inhibitor, also referenced under CAS 915754-88-0, controls the biological activity of sFRP-1. This small molecule/inhibitor is primarily used for Activators/Inducers applications. Less<<
MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
A diphenylsulfone-sulfonamide compound that counteracts the antagonizing effect of SARP-2/sFRP-1 (secreted frizzled related protein-1) against Wnt-3/frizzled interaction and Wnt-3/frizzled-stimulated cellular functions (EC50 = 1.27 µM in a U2OS-based reporter assay) with a reported aqueous solubility of 26 µg/ml at pH 7.4 and in vitro half-lives of 12 and 26.7 min using rat and human microsomes, respectively.
Catalogue Number
344300
Brand Family
Calbiochem®
Synonyms
N-(3-(Dimethylamino)propyl)-2-ethyl-5-(phenylsulfonyl)benzenesulfonamide, Secreted Frizzled Related Protein-1 Inhibitor, Wnt Pathway Activator IV
References
References
Gopalsamy, A., et al. 2008. J. Med. Chem.51, 7670.
sFRP-1 Inhibitor - CAS 915754-88-0 - Calbiochem 分析证书
标题
批号
344300
参考
参考信息概述
Gopalsamy, A., et al. 2008. J. Med. Chem.51, 7670.
数据表
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
08-April-2011 RFH
Synonyms
N-(3-(Dimethylamino)propyl)-2-ethyl-5-(phenylsulfonyl)benzenesulfonamide, Secreted Frizzled Related Protein-1 Inhibitor, Wnt Pathway Activator IV
Description
A diphenylsulfone-sulfonamide compound that counteracts the antagonizing effect of SARP-2/sFRP-1 (secreted frizzled related protein-1) against Wnt-3/frizzled interaction and Wnt-3/frizzled-stimulated cellular functions (EC50 = 1.27 µM in a U2OS-based reporter assay) with a reported aqueous solubility of 26 µg/ml at pH 7.4 and in vitro half-lives of 12 and 26.7 min using rat and human microsomes, respectively.
Form
Clear oil
Intert gas (Yes/No)
Packaged under inert gas
CAS number
915754-88-0
Chemical formula
C₁₉H₂₆N₂O₄S₂
Structure formula
Purity
≥95% by HPLC
Solubility
DMSO (5 mg/ml)
Storage
Protect from light
+2°C to +8°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity
Standard Handling
References
Gopalsamy, A., et al. 2008. J. Med. Chem.51, 7670.
