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324516 Sigma-AldricheEF2K Inhibitor, A-484954 - CAS 142557-61-7 - Calbiochem

eEF2K Inhibitor, A-484954, CAS 142557-61-7, is a cell-permeable, highly potent, selective inhibitor of eukaryotic elongation factor-2 kinase (eEF2K) (IC50= 280 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: 7-amino-1-cyclopropyl-3-ethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-6-carboxamide, Eukaryotic elongation factor-2 kinase inhibitor, A-484954

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
142557-61-7	C₁₃H₁₅N₅O₃

价格及供货情况

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Description
Overview	A cell-permeable pyrido-pyrimidinedione derivative that acts as a highly potent and selective inhibitor of eukaryotic elongation factor-2 kinase (eEF2K) (IC₅₀= 280 nM). Exhibits very little activity against a broad panel of serine/threonine and protein tyrosine kinases. Inhibits eEF2 phosphorylation in multiple cell lines tested without affecting the net eEF2 levels. At concentration where it inhibits eEF2K activity, it has no effect on the proliferation of cancer cell lines.
Catalogue Number	324516
Brand Family	Calbiochem®
Synonyms	7-amino-1-cyclopropyl-3-ethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-6-carboxamide, Eukaryotic elongation factor-2 kinase inhibitor, A-484954

References
References	Chen, Z., et al. 2011. J. Bio. Chem. 286, 43951.

Product Information
CAS number	142557-61-7
Form	Off-white powder
Hill Formula	C₁₃H₁₅N₅O₃
Chemical formula	C₁₃H₁₅N₅O₃
Structure formula Image
Quality Level	MQ100

Applications
Application	eEF2K Inhibitor, A-484954, CAS 142557-61-7, is a cell-permeable, highly potent, selective inhibitor of eukaryotic elongation factor-2 kinase (eEF2K) (IC50= 280 nM).

Biological Information
Purity	≥98% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
324516-10MGCN	04055977197310

Documentation

eEF2K Inhibitor, A-484954 - CAS 142557-61-7 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

eEF2K Inhibitor, A-484954 - CAS 142557-61-7 - Calbiochem 分析证书

标题	批号
324516	输入批号

参考

参考信息概述
Chen, Z., et al. 2011. J. Bio. Chem. 286, 43951.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	13-July-2012 JSW
Synonyms	7-amino-1-cyclopropyl-3-ethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-6-carboxamide, Eukaryotic elongation factor-2 kinase inhibitor, A-484954
Description	A cell-permeable pyrido-pyrimidinedione derivative that acts as a highly potent and selective inhibitor of eukaryotic elongation factor-2 kinase (eEF2K) (IC₅₀= 280 nM). Exhibits very little activity against a broad panel of serine/threonine and protein tyrosine kinases. Inhibits eEF2 phosphorylation in multiple cell lines tested without affecting the net eEF2 levels. At concentration where it inhibits eEF2K activity, it has no effect on the proliferation of cancer cell lines.
Form	Off-white powder
Intert gas (Yes/No)	Packaged under inert gas
CAS number	142557-61-7
Chemical formula	C₁₃H₁₅N₅O₃
Structure formula
Purity	≥98% by HPLC
Solubility	DMSO (2.5 mg/ml; clear, colorless solution)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Chen, Z., et al. 2011. J. Bio. Chem. 286, 43951.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > eEF-2 Kinase Inhibitors

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