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324515 Sigma-AldricheEF-2 Kinase Inhibitor, NH125 - CAS 278603-08-0 - Calbiochem

The eEF-2 Kinase Inhibitor, NH125, also referenced under CAS 278603-08-0, controls the biological activity of eEF-2 Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: 1-Benzyl-3-cetyl-2-methylimidazolium iodide, 1-Cetyl-3-benzyl-2-methylimidazolium iodide, CaM-Dependent Kinase III Inhibitor, NH125

Primary Target: Bacterial histidine kinases (EnvZ, PhoQ, BvgS, and EvgS) and eukaryotic eEF-2 (elongation factor 2) kinase/CaMKIII

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
278603-08-0	C₂₇H₄₅IN₂

价格及供货情况

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Description
Overview	A cell-permeable imidazolium compound that inhibits the activity of bacterial histidine kinases (EnvZ, PhoQ, BvgS, and EvgS) and eukaryotic eEF-2 (elongation factor 2) kinase/CaMKIII (IC₅₀ = 60 nM), while exhibiting much lower potency against PKC, PKA, and CaMKII (IC₅₀ = 7.5, 80, and >100 µM, respectively). NIH125 is a known P-gp substrate, which limits its in vivo efficacy as an anticancer and antimicrobial agent.
Catalogue Number	324515
Brand Family	Calbiochem®
Synonyms	1-Benzyl-3-cetyl-2-methylimidazolium iodide, 1-Cetyl-3-benzyl-2-methylimidazolium iodide, CaM-Dependent Kinase III Inhibitor, NH125

References
References	Arora, S., et al. 2004. Mol. Pharmacol. 66, 460. Arora, S., et al. 2003. Cancer Res. 63, 6894. Yamamoto, K., et al. 2000. Biosci. Biotechnol. Biochem. 64, 919.

Product Information
CAS number	278603-08-0
ATP Competitive	N
Form	White to yellow solid
Hill Formula	C₂₇H₄₅IN₂
Chemical formula	C₂₇H₄₅IN₂
Hygroscopic	Hygroscopic
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Bacterial histidine kinases (EnvZ, PhoQ, BvgS, and EvgS) and eukaryotic eEF-2 (elongation factor 2) kinase/CaMKIII
Primary Target IC<sub>50</sub>	60 nM against the activity of bacterial histidine kinases (EnvZ, PhoQ, BvgS, and EvgS) and eukaryotic eEF-2 (elongation factor 2) kinase/CaMKIII
Purity	≥95% by NMR

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information
R Phrase	R: 36/37/38 Irritating to eyes, respiratory system and skin.
S Phrase	S: 26-36 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing.

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Irritant
Storage	+2°C to +8°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
324515-5MGCN	04055977197303

Documentation

eEF-2 Kinase Inhibitor, NH125 - CAS 278603-08-0 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

eEF-2 Kinase Inhibitor, NH125 - CAS 278603-08-0 - Calbiochem 分析证书

标题	批号
324515	输入批号

参考

参考信息概述
Arora, S., et al. 2004. Mol. Pharmacol. 66, 460. Arora, S., et al. 2003. Cancer Res. 63, 6894. Yamamoto, K., et al. 2000. Biosci. Biotechnol. Biochem. 64, 919.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	24-August-2023 JSW
Synonyms	1-Benzyl-3-cetyl-2-methylimidazolium iodide, 1-Cetyl-3-benzyl-2-methylimidazolium iodide, CaM-Dependent Kinase III Inhibitor, NH125
Description	A cell-permeable imidazolium compound that inhibits the activity of bacterial histidine kinases (EnvZ, PhoQ, BvgS, and EvgS) and eukaryotic eEF-2 (elongation factor 2) kinase/CaMKIII (IC₅₀ = 60 nM), while exhibiting much lower potency against PKC, PKA, and CaMKII (IC₅₀ = 7.5, 80, and >100 µM, respectively). NIH125 is a known P-gp substrate, which limits its in vivo efficacy as an anticancer and antimicrobial agent.
Form	White to yellow solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	278603-08-0
Chemical formula	C₂₇H₄₅IN₂
Structure formula
Purity	≥95% by NMR
Solubility	DMSO (20 mg/ml) or 70% Ethanol (5 mg/ml)
Storage	Protect from light +2°C to +8°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Irritant
References	Arora, S., et al. 2004. Mol. Pharmacol. 66, 460. Arora, S., et al. 2003. Cancer Res. 63, 6894. Yamamoto, K., et al. 2000. Biosci. Biotechnol. Biochem. 64, 919.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > eEF-2 Kinase Inhibitors

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