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A cell-permeable chemically stable cytidine analog that displays antitumor properties. Acts as transition state analog inhibitor of cytidine deaminase by binding at the active site as covalent hydrates. Also shown to inhibit DNA methylation and tumor growth both in vitro and in vivo.
Cheng, J.C., et al. 2004. Cancer Cell6, 151. Cheng, J.C., et al. 2003. J. Natl. Cancer Inst.95, 399. Zhou, L., et al. 2002. J. Mol. Biol.321, 591. Barchi, J.J., Jr., et al. 1992. J. Org. Chem.57, 536. Frick, L., et al. 1989. Biochemistry28, 9423.
Cheng, J.C., et al. 2004. Cancer Cell6, 151. Cheng, J.C., et al. 2003. J. Natl. Cancer Inst.95, 399. Zhou, L., et al. 2002. J. Mol. Biol.321, 591. Barchi, J.J., Jr., et al. 1992. J. Org. Chem.57, 536. Frick, L., et al. 1989. Biochemistry28, 9423.
数据表
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A chemically stable, cytidine analog that displays anti-tumor properties. Acts as a transition state analog inhibitor of cytidine deaminase by binding to the active size as covalent hydrates. Also shown to inhibit DNA methylation and tumor growth both in vitro and in vivo.
Form
Off-white solid
Intert gas (Yes/No)
Packaged under inert gas
CAS number
3690-10-6
Chemical formula
C₉H₁₂N₂O₅
Structure formula
Purity
≥95% by HPLC
Solubility
DMSO (5 mg/ml) or Methanol (5 mg/ml). Slight warming may be required to achieve complete solubilization.
Storage
+2°C to +8°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
From Catalog: Desc. Field- added "cell-permeable
Toxicity
Standard Handling
References
Cheng, J.C., et al. 2004. Cancer Cell6, 151. Cheng, J.C., et al. 2003. J. Natl. Cancer Inst.95, 399. Zhou, L., et al. 2002. J. Mol. Biol.321, 591. Barchi, J.J., Jr., et al. 1992. J. Org. Chem.57, 536. Frick, L., et al. 1989. Biochemistry28, 9423.
