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			96-Well Plate

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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

682160 Sigma-AldrichXestospongin C, Xestospongia sp. - Calbiochem

Xestospongin C, Xestospongia sp. CAS 88903-69-9, is a highly potent, reversible, and membrane-permeable blocker of IP3-mediated Ca2+ release (IC50 = 358 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet
Citations

同义词: XeC

Primary Target: IP3-mediated Ca2+ release

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概述

Replacement Information

重要规格表

Empirical Formula
C₂₈H₅₀N₂O₂

价格及供货情况

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Description
Overview	An oxaquinolizidine alkaloid isolated from a marine sponge. A very potent, reversible, and membrane-permeable blocker of IP₃-mediated Ca²⁺ release (IC₅₀ = 358 nM) that does not interact with the IP₃-binding site. Displays high selectivity over the skeletal isoform of the ryanodine receptor type 1 (RyR-1). Also blocks bradykinin- and carbamylcholine-induced Ca²⁺ efflux from the endoplasmic reticulum stores in a reversible manner.
Catalogue Number	682160
Brand Family	Calbiochem®
Synonyms	XeC

References
References	Oka, T., et al. 2002. Br. J. Pharmacol. 135, 1959. Gafni, J., et al. 1997. Neuron 19, 723. Tinker, A., and Williams, A.J. 1995. Biophys. J. 68, 111. Callaway, C., et al. 1994. J. Biol. Chem. 269, 15876. Quirion, J.C., et al. 1992. J. Nat. Prod. 55, 1505. Nakagawa, M., et al. 1984. Tetrahedron Lett. 25, 3227.

Product Information
ATP Competitive	N
Form	White to off-white film
Hill Formula	C₂₈H₅₀N₂O₂
Chemical formula	C₂₈H₅₀N₂O₂
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications
Application	Xestospongin C, Xestospongia sp. CAS 88903-69-9, is a highly potent, reversible, and membrane-permeable blocker of IP3-mediated Ca2+ release (IC50 = 358 nM).

Biological Information
Primary Target	IP3-mediated Ca2+ release
Primary Target IC<sub>50</sub>	358 nM in blocking IP3-mediated Ca2+ release
Purity	≥98% by TLC or HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information
R Phrase	R: 20/21/22 Harmful by inhalation, in contact with skin and if swallowed.
S Phrase	S: 22-24/25-36/37/39-45 Do not breathe dust. Avoid contact with skin and eyes. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Harmful
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
682160-10UGCN	07790788052355

Documentation

Xestospongin C, Xestospongia sp. - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Xestospongin C, Xestospongia sp. - Calbiochem 分析证书

标题	批号
682160	输入批号

参考

参考信息概述
Oka, T., et al. 2002. Br. J. Pharmacol. 135, 1959. Gafni, J., et al. 1997. Neuron 19, 723. Tinker, A., and Williams, A.J. 1995. Biophys. J. 68, 111. Callaway, C., et al. 1994. J. Biol. Chem. 269, 15876. Quirion, J.C., et al. 1992. J. Nat. Prod. 55, 1505. Nakagawa, M., et al. 1984. Tetrahedron Lett. 25, 3227.

引用

标题

M. Keith Wilkerson, et al. (2006) Inositol triphosphate receptor calcium release is required for cerebral artery smooth muscle cell proliferation. American Journal of Physiology Heart and Circulatory Physiology 290, H240-H247.

Tobi L. Limke, Jeremy J. Bearss and William D. Atchison. (2004) Acute Exposure to Methylmercury Causes Ca2+ Dysregulation and Neuronal Death in Rat Cerebellar Granule Cells through an M3 Muscarinic Receptor-Linked Pathway. Toxicological Sciences 80, 60-68.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	13-October-2020 JSW
Synonyms	XeC
Description	A macrocyclic bis-1-oxaquinolizidine natural product isolated from a marine sponge. A very potent, reversible and membrane-permeable blocker of IP₃-mediated Ca²⁺ release (IC₅₀ = 358 nM) that does not interact with the IP₃-binding site. Displays high selectivity over the skeletal isoform of the ryanodine receptor type 1 (Ry₁R). Also blocks bradykinin- and carbamylcholine-induced Ca²⁺ efflux from the ER stores in a reversible manner.
Form	White to off-white film
Intert gas (Yes/No)	Packaged under inert gas
Chemical formula	C₂₈H₅₀N₂O₂
Structure formula
Purity	≥98% by TLC or HPLC
Solubility	DMSO (1 mg/ml), Ethanol (1 mg/ml), or Methanol (1 mg/ml). Sonication may be required to achieve complete solubilization.
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Harmful
References	Oka, T., et al. 2002. Br. J. Pharmacol. 135, 1959. Gafni, J., et al. 1997. Neuron 19, 723. Tinker, A., and Williams, A.J. 1995. Biophys. J. 68, 111. Callaway, C., et al. 1994. J. Biol. Chem. 269, 15876. Quirion, J.C., et al. 1992. J. Nat. Prod. 55, 1505. Nakagawa, M., et al. 1984. Tetrahedron Lett. 25, 3227.
Citation	M. Keith Wilkerson, et al. (2006) Inositol triphosphate receptor calcium release is required for cerebral artery smooth muscle cell proliferation. American Journal of Physiology Heart and Circulatory Physiology 290, H240-H247. Tobi L. Limke, Jeremy J. Bearss and William D. Atchison. (2004) Acute Exposure to Methylmercury Causes Ca2+ Dysregulation and Neuronal Death in Rat Cerebellar Granule Cells through an M3 Muscarinic Receptor-Linked Pathway. Toxicological Sciences 80, 60-68.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Calcium Signaling > IP3 and Ryanodine Channel Modulators

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