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			96-Well Plate

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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

681672 Sigma-AldrichWnt/β-catenin Inhibitor, Cardamonin - CAS 19309-14-9 - Calbiochem

The Wnt/β-catenin Inhibitor, Cardamonin, also referenced under CAS 19309-14-9, controls the biological activity of Wnt/β-catenin. This small molecule/inhibitor is primarily used for Cancer applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
Data Sheet

同义词: Wnt Pathway Inhibitor VII, Cardamonin, (E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenylprop-2-en-1-one

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
19309-14-9	C₁₆H₁₄O₄

价格及供货情况

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Description
Overview	Cardamonin, a known 2',4'-dihydroxy-6'-methoxychalcone, was identified as an inhibitor of melanocyte differentiation, among many other pharmacology activities. Cardamonin promoted degradation of intracellular β-catenin while suppressing melanogenesis by down-regulating the expression of MITF and tyrosinase, resulting in decreased melanin content. Furthermore, it was found that cardamonin promoted the degradation of β-catenin through a GSK-3β-independent mechanism, which suggested that Siah-dependent pathway and/or a PKCα-dependent pathway, rather than a GSK-3β-dependent pathway, may mediate intracellularb-catenin degradation by cardamonin.
Catalogue Number	681672
Brand Family	Calbiochem®
Synonyms	Wnt Pathway Inhibitor VII, Cardamonin, (E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenylprop-2-en-1-one

References

Product Information
CAS number	19309-14-9
Form	Orange-yellow to amber solid
Hill Formula	C₁₆H₁₄O₄
Chemical formula	C₁₆H₁₄O₄
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	≥95% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
681672-2MGCN	04055977225204

Documentation

Wnt/β-catenin Inhibitor, Cardamonin - CAS 19309-14-9 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Wnt/β-catenin Inhibitor, Cardamonin - CAS 19309-14-9 - Calbiochem 分析证书

标题	批号
681672	输入批号

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	30-August-2010 RFH
Synonyms	Wnt Pathway Inhibitor VII, Cardamonin, (E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenylprop-2-en-1-one
Description	Cardamonin, a known 2',4'-dihydroxy-6'-methoxychalcone, was recently identified as an inhibitor of melanocyte differentiation, among many other pharmacology activities. Cardamonin promoted degradation of intracellular β-catenin while suppressing melanogenesis by down-regulating the expression of MITF and tyrosinase, resulting in decreased melanin content. Furthermore, it was found that cardamonin promoted the degradation of β-catenin through a GSK-3β-independent mechanism, which suggested that Siah-dependent pathway and/or a PKCa-dependent pathway, rather than a GSK-3&beta:-dependent pathway, may mediate intracellularb-catenin degradation by cardamonin.
Form	Orange-yellow to amber solid
CAS number	19309-14-9
Chemical formula	C₁₆H₁₄O₄
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (100 mg/ml) or Ethanol (5 mg/ml)
Storage	-20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest

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