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681668 Sigma-AldrichWnt Synergist, QS11 - CAS 944328-88-5 - Calbiochem

A cell-permeable purine compound that binds ARFGAPs (Kd = 364 and 620 nM for AMAP1 and ARFGAP1, respectively) and acts as a broad specificity ARFGAPs inhibitor (GTPase activating proteins of ADP-ribosylation factor).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: QS11, Wnt Pathway Activator II

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
944328-88-5	C₃₆H₃₃N₅O₂

价格及供货情况

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Description
Overview	A cell-permeable purine compound that binds ARFGAPs (K_d = 364 and 620 nM for AMAP1 and ARFGAP1, respectively) and acts as a broad specificity ARFGAPs inhibitor (GTPase activating proteins of ADP-ribosylation factor). Shown to synergize with Wnt-3a and specifically activate the canonical Wnt/β-catenin signaling pathway both in vitro (2-, 40-, and 200-fold increase of basal transcription activity by QS11, Wnt-3a, and QS11/Wnt-3a, respectively, in a Super(8X)TOPFlash reporter assay using HEK293 cells) and in vivo (in the induction of Xenopus embryonic axis duplication). Also reported to block the migration of AMAP1-overexpressing MDA-MB-231 cells (86% inhibition at 2.5 µM).
Catalogue Number	681668
Brand Family	Calbiochem®
Synonyms	QS11, Wnt Pathway Activator II

References
References	Zhang, Q., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 7444.

Product Information
CAS number	944328-88-5
Form	Pale amber solid
Hill Formula	C₃₆H₃₃N₅O₂
Chemical formula	C₃₆H₃₃N₅O₂
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	≥95% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Regulatory Review
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
681668-5MGCN	04055977260267

Documentation

Wnt Synergist, QS11 - CAS 944328-88-5 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Wnt Synergist, QS11 - CAS 944328-88-5 - Calbiochem 分析证书

标题	批号
681668	输入批号

参考

参考信息概述
Zhang, Q., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 7444.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	04-April-2011 RFH
Synonyms	QS11, Wnt Pathway Activator II
Description	A cell-permeable purine compound that binds ARFGAPs (K_d = 364 and 620 nM for AMAP1 and ARFGAP1, respectively) and acts as a broad specificity ARFGAPs inhibitor (GTPase activating proteins of ADP-ribosylation factor). Shown to synergize with Wnt-3a and specifically activate the canonical Wnt/β-catenin signaling pathway both in vitro (2-, 40-, and 200-fold increase of basal transcription activity by QS11, Wnt-3a, and QS11/Wnt-3a, respectively, in a Super(8X)TOPFlash reporter assay using HEK293 cells) and in vivo (in the induction of Xenopus embryonic axis duplication). Also reported to block the migration of AMAP1-overexpressing MDA-MB-231 cells (86% inhibition at 2.5 µM).
Form	Pale amber solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	944328-88-5
Chemical formula	C₃₆H₃₃N₅O₂
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (50 mg/ml) or Ethanol (20 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Regulatory Review
References	Zhang, Q., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 7444.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Stem Cell Biology > Wnt Signaling Inhibitors

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