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681673 Sigma-AldrichWnt Antagonist III, Box5 - Calbiochem

Wnt Antagonist III, Box5, is a Wnt-5a-derived hexapeptide that antagonizes Wnt-5a-mediated cellular activities in A2058 and HTB63 melanoma cultures, including migration and invasion.

Wnt Antagonist III, Box5 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: Wnt-5a Antagonist, Wnt Pathway Inhibitor VI, Boc-MDGCEL-OH, Frizzled-5 Antagonist

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概述

Replacement Information

重要规格表

Empirical Formula
C₃₀H₅₀N₆O₁₃S₂

价格及供货情况

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Description
Overview	A Wnt-5a-derived, N-terminally butyloxycarbonyl- (Boc) protected, hexa-peptide that effectively antagonizes Wnt-5a-mediated cellular activities in A2058 and HTB63 melanoma cultures, including migration, invasion, calcium response, and MARCKS phosphorylation. Replacing the N-terminal Boc with a formyl modification results in a peptide termed Foxy5 that mimics, instead of antagonizes, Wnt-5a biological activity in a Frizzled-5- (Fzd-5/Frz-5) dependent manner. The peptide sequence is conserved in multiple species, including human, mouse, and rat, and Box5 is expected to exert its effect via direct FZD5 binding as is the case with Foxy5.
Catalogue Number	681673
Brand Family	Calbiochem®
Synonyms	Wnt-5a Antagonist, Wnt Pathway Inhibitor VI, Boc-MDGCEL-OH, Frizzled-5 Antagonist

References
References	Jenei, V., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 19473. Safholm, A., et al. 2006. J. Biol. Chem. 281, 2740.

Product Information
Form	White lyophilized solid
Hill Formula	C₃₀H₅₀N₆O₁₃S₂
Chemical formula	C₃₀H₅₀N₆O₁₃S₂
Quality Level	MQ100

Applications
Application	Wnt Antagonist III, Box5, is a Wnt-5a-derived hexapeptide that antagonizes Wnt-5a-mediated cellular activities in A2058 and HTB63 melanoma cultures, including migration and invasion.

Biological Information
Purity	≥90% by HPLC

Physicochemical Information
Peptide Sequence	t-Boc-NH-Met-Asp-Gly-Cys-Glu-Leu-CO₂H

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped with Blue Ice or with Dry Ice
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
681673-10MGCN	04055977225211

Documentation

Wnt Antagonist III, Box5 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Wnt Antagonist III, Box5 - Calbiochem 分析证书

标题	批号
681673	输入批号

参考

参考信息概述
Jenei, V., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 19473. Safholm, A., et al. 2006. J. Biol. Chem. 281, 2740.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	07-December-2010 RFH
Synonyms	Wnt-5a Antagonist, Wnt Pathway Inhibitor VI, Boc-MDGCEL-OH, Frizzled-5 Antagonist
Description	A Wnt-5a-derived, N-terminally butyloxycarbonyl- (Boc) protected, hexa-peptide that effectively antagonizes Wnt-5a-mediated cellular activities in A2058 and HTB63 melanoma cultures, including migration, invasion, calcium response, and MARCKS phosphorylation. Replacing the N-terminal Boc with a formyl modification results in a peptide termed Foxy5 that mimics, instead of antagonizes, Wnt-5a biological activity in a Frizzled-5- (Fzd-5/Frz-5) dependent manner. The peptide sequence is conserved in multiple species, including human, mouse, and rat, and Box5 is expected to exert its effect via direct FZD5 binding as is the case with Foxy5.
Form	White lyophilized solid
Intert gas (Yes/No)	Packaged under inert gas
Chemical formula	C₃₀H₅₀N₆O₁₃S₂
Peptide Sequence	t-Boc-NH-Met-Asp-Gly-Cys-Glu-Leu-CO₂H
Purity	≥90% by HPLC
Solubility	DMSO (50 mg/ml) or H₂O (4 mg/ml)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Jenei, V., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 19473. Safholm, A., et al. 2006. J. Biol. Chem. 281, 2740.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Stem Cell Biology > Wnt Signaling Inhibitors

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