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681665 Sigma-AldrichWnt Agonist - CAS 853220-52-7 - Calbiochem

Wnt Agonist, CAS 853220-52-7, is a cell-permeable, potent, and selective activator of Wnt signaling. Does not inhibit the activity of GSK-3β (IC50 greater than 60 µM).

Wnt Agonist - CAS 853220-52-7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: 2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine, Wnt Pathway Activator I

Primary Target: Selective activator of Wnt signaling

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
853220-52-7	C₁₉H₁₈N₄O₃

价格及供货情况

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Description
Overview	A cell-permeable pyrimidine compound that acts as a potent and selective activator of Wnt signaling without inhibiting the activity of GSK-3β (IC₅₀ > 60 µM). Shown to mimic the effect of Wnt and induce β-catenin and TCF (T-cell fate)-dependent transcriptional activity (EC₅₀ = 700 nM in HEK-293T cells), and cause substantial head defects during Xenopus embryonic development. Also available as a 10 mM solution in DMSO (Cat. No. 681664).
Catalogue Number	681665
Brand Family	Calbiochem®
Synonyms	2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine, Wnt Pathway Activator I

References
References	Liu, J., et al. 2005. Angew. Chem. Int. Ed. 44, 1987.

Product Information
CAS number	853220-52-7
ATP Competitive	N
Form	Yellowish sticky solid
Hill Formula	C₁₉H₁₈N₄O₃
Chemical formula	C₁₉H₁₈N₄O₃
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications
Application	Wnt Agonist, CAS 853220-52-7, is a cell-permeable, potent, and selective activator of Wnt signaling. Does not inhibit the activity of GSK-3β (IC50 greater than 60 µM).

Biological Information
Primary Target	Selective activator of Wnt signaling
Primary Target IC<sub>50</sub>	EC50 = 700 nM inducing β-catenin and TCF (T-cell fate)-dependent transcriptional activity in HEK-293T cells
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
681665-5MGCN	04055977260236

Documentation

Wnt Agonist - CAS 853220-52-7 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Wnt Agonist - CAS 853220-52-7 - Calbiochem 分析证书

标题	批号
681665	输入批号

参考

参考信息概述
Liu, J., et al. 2005. Angew. Chem. Int. Ed. 44, 1987.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	19-April-2011 RFH
Synonyms	2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine, Wnt Pathway Activator I
Description	A cell-permeable, potent, and selective activator of Wnt signaling that does not inhibit the activity of GSK-3β (IC₅₀ >60 µM). Shown to mimic the effect of Wnt and induce β-catenin and TCF (T-cell fate)-dependent transcriptional activity (EC₅₀ = 700 nM in HEK-293T cells). Reported to cause substantial head defects during Xenopus embryonic development.
Form	Yellowish sticky solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	853220-52-7
Chemical formula	C₁₉H₁₈N₄O₃
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (10 mg/ml) or Ethanol (5 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Standard Handling
References	Liu, J., et al. 2005. Angew. Chem. Int. Ed. 44, 1987.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Inducers > Cell Differentiation Inducers

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