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			96-Well Plate

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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

681535 Sigma-AldrichWithaferin A, Withania somnifera - CAS 5119-48-2 - Calbiochem

A cell-permeable steroidal lactone that displays antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

Primary Target: A steroidal lactone that displays antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties.

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
5119-48-2	C₂₈H₃₈O₆

价格及供货情况

产品目录编号	库存情况	包装	数量 / 包装	价格	数量
681535-1MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	塑胶安瓿;塑胶针药瓶	1 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹
681535-5MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	塑胶安瓿;塑胶针药瓶	5 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹

Description
Overview	A cell-permeable steroidal lactone that displays antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties. Potently inhibits angiogenesis both in vitro (IC₅₀ = 12 nM against HUVEC proliferation) and in vivo (80% inhibition at 7 µg/kg/day in C57BL/6J mice, s.c.) and NF-κB activation (IC₅₀ = 500 nM in TNF-α-induced endothelial cells) by targeting the ubiquitin-mediated proteasome pathway. At higher concentrations (~5 µM) also affects AP-1 transcription and induces cell death.
Catalogue Number	681535
Brand Family	Calbiochem®

References
References	Mohan, R., et al. 2004. Angiogenesis 7, 115. Jeyaprakasam, B., et al. 2003. Life Sci. 74, 125. Devi, P.U., et al. 1995. Cancer Lett. 95, 189. Kupchan, S.M., et al. 1969. J. Org. Chem. 34, 3858.

Product Information
CAS number	5119-48-2
ATP Competitive	N
Form	White solid
Hill Formula	C₂₈H₃₈O₆
Chemical formula	C₂₈H₃₈O₆
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	A steroidal lactone that displays antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties.
Primary Target IC<sub>50</sub>	12 nM against angiogenesis in vitro by inhibiting HUVEC proliferation
Purity	≥94% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	KE7288500

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity	Carcinogenic / Teratogenic
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
681535-1MGCN	04055977260113
681535-5MGCN	04055977260120

Documentation

Withaferin A, Withania somnifera - CAS 5119-48-2 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Withaferin A, Withania somnifera - CAS 5119-48-2 - Calbiochem 分析证书

标题	批号
681535	输入批号

参考

参考信息概述
Mohan, R., et al. 2004. Angiogenesis 7, 115. Jeyaprakasam, B., et al. 2003. Life Sci. 74, 125. Devi, P.U., et al. 1995. Cancer Lett. 95, 189. Kupchan, S.M., et al. 1969. J. Org. Chem. 34, 3858.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	16-September-2008 RFH
Description	A cell-permeable steroidal lactone that displays antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties. Potently inhibits angiogenesis both in vitro (IC₅₀ = 12 nM against HUVEC proliferation) and in vivo (80% inhibition at 7 µg/kg/day in C57BL/6J mice, s.c.) and NF-κB activation (IC₅₀ = 500 nM in TNF-α-induced endothelial cells) by targeting the ubiquitin-mediated proteasome pathway. At higher concentrations (~5 µM) also affects AP-1 transcription and induces cell death.
Form	White solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	5119-48-2
RTECS	KE7288500
Chemical formula	C₂₈H₃₈O₆
Structure formula
Purity	≥94% by HPLC
Solubility	DMSO (10 mg/ml) or Ethanol (5 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Carcinogenic / Teratogenic
References	Mohan, R., et al. 2004. Angiogenesis 7, 115. Jeyaprakasam, B., et al. 2003. Life Sci. 74, 125. Devi, P.U., et al. 1995. Cancer Lett. 95, 189. Kupchan, S.M., et al. 1969. J. Org. Chem. 34, 3858.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Angiogenesis Inhibitors > Angiogenesis Inhibitors

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