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681640 Sigma-AldrichWee1 Inhibitor - CAS 622855-37-2 - Calbiochem

The Wee1 Inhibitor, also referenced under CAS 622855-37-2, controls the biological activity of Wee1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: 4-(2-Chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3-(2H,6H)-dione, Chk1 Inhibitor V

Primary Target: Wee1

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
622855-37-2	C₂₀H₁₁ClN₂O₃

价格及供货情况

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Description
Overview	A pyrrolocarbazole compound that acts as a potent, ATP-binding site-targeting inhibitor of Wee1 (IC₅₀ = 11 nM) in an ATP-competitive manner and displays ~40-fold selectivity over the related checkpoint kinase Chk1 (IC₅₀ = 440 nM).
Catalogue Number	681640
Brand Family	Calbiochem®
Synonyms	4-(2-Chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3-(2H,6H)-dione, Chk1 Inhibitor V

References
References	Palmer, B.D., et al. 2006. J. Med. Chem. 49, 4896.

Product Information
CAS number	622855-37-2
ATP Competitive	Y
Form	Light orange solid
Hill Formula	C₂₀H₁₁ClN₂O₃
Chemical formula	C₂₀H₁₁ClN₂O₃
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Wee1
Primary Target IC<sub>50</sub>	11 nM
Purity	≥97% by HPLC

Physicochemical Information
Cell permeable	N

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
681640-1MGCN	04055977260182

Documentation

Wee1 Inhibitor - CAS 622855-37-2 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Wee1 Inhibitor - CAS 622855-37-2 - Calbiochem 分析证书

标题	批号
681640	输入批号

参考

参考信息概述
Palmer, B.D., et al. 2006. J. Med. Chem. 49, 4896.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	19-April-2011 RFH
Synonyms	4-(2-Chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3-(2H,6H)-dione, Chk1 Inhibitor V
Description	A pyrrolocarbazole compound that acts as a poten, ATP-binding site-targeting inhibitor of Wee1 (IC₅₀ = 11 nM) in an ATP-competitive manner and displays ~40-fold selectivity over the related checkpoint kinase Chk1 (IC₅₀ = 440 nM).
Form	Light orange solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	622855-37-2
Chemical formula	C₂₀H₁₁ClN₂O₃
Structure formula
Purity	≥97% by HPLC
Solubility	DMSO (10 mg/ml) or Ethanol (10 mg/ml)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Standard Handling
References	Palmer, B.D., et al. 2006. J. Med. Chem. 49, 4896.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Cell Cycle/Cell Division > Checkpoint Kinase Inhibitors

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