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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

679101 MilliporeVitamin D₃, 1α, 25-Dihydroxy- - CAS 32222-06-3 - Calbiochem

CAS 32222-06-3 prevents the development of clinical diabetes in NOD mice, an animal model of human autoimmune diabetes.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: 1,25-(OH)₂-D₃, Calcitriol

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
32222-06-3	C₂₇H₄₄O₃

价格及供货情况

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Description
Overview	Has immunomodulatory properties in vitro and in vivo. Prevents the development of clinical diabetes in NOD mice, an animal model of human autoimmune diabetes. Regulates c-myc transcription. Induces reversible hydrolysis of sphingomyelin cycle and generates ceramide. Stimulates intestinal Ca²⁺ and phosphate transport and mobilizes Ca²⁺ from bone. Also available as a 1 mM solution in DMSO (Cat. No. 509721).
Catalogue Number	679101
Brand Family	Calbiochem®
Synonyms	1,25-(OH)₂-D₃, Calcitriol

References
References	Semizarov, D., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 15412. Hannun, Y.A. 1994. J. Biol. Chem. 269, 3125. Mathieu, C., et al. 1994. Diabetologica 37, 552. Thomasset, M. 1994. Pathol. Biol. 42, 163. Horton, W.E., Jr., et al. 1991. J. Biol. Chem. 266, 24804. Larsen, C.G., et al. 1991. Biochem. Biophys. Res. Commun. 176, 1020. Thavarajah, M., et al. 1991. Biochem. Biophys. Res. Commun. 176, 1189. Wakasugi, M., et al. 1991. Prostaglandins 42, 127. Matsumoto, K., et al. 1990. Biochem. Biophys. Res. Commun. 166, 916. Simpson, R.U., et al. 1989. J. Biol. Chem. 264, 19710. DeLuca, H.F., and Schnoes, H.K. 1983. Annu. Rev. Biochem. 52, 411.

References

Semizarov, D., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 15412.
Hannun, Y.A. 1994. J. Biol. Chem. 269, 3125.
Mathieu, C., et al. 1994. Diabetologica 37, 552.
Thomasset, M. 1994. Pathol. Biol. 42, 163.
Horton, W.E., Jr., et al. 1991. J. Biol. Chem. 266, 24804.
Larsen, C.G., et al. 1991. Biochem. Biophys. Res. Commun. 176, 1020.
Thavarajah, M., et al. 1991. Biochem. Biophys. Res. Commun. 176, 1189.
Wakasugi, M., et al. 1991. Prostaglandins 42, 127.
Matsumoto, K., et al. 1990. Biochem. Biophys. Res. Commun. 166, 916.
Simpson, R.U., et al. 1989. J. Biol. Chem. 264, 19710.
DeLuca, H.F., and Schnoes, H.K. 1983. Annu. Rev. Biochem. 52, 411.

Product Information
CAS number	32222-06-3
Form	Solid
Hill Formula	C₂₇H₄₄O₃
Chemical formula	C₂₇H₄₄O₃
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	≥95% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	FZ4645000

Safety Information
R Phrase	R: 26/27/28-63 Very toxic by inhalation, in contact with skin and if swallowed. Possible risk of harm to the unborn child.
S Phrase	S: 36/37/39-45 Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

Product Usage Statements

Storage and Shipping Information
Ship Code	Blue Ice Only
Toxicity	Highly Toxic & Carcinogenic / Teratogenic
Hazardous Materials Attention:	Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage	≤ -70°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
679101-50UGCN	07790788052348

Documentation

Vitamin D₃, 1α, 25-Dihydroxy- - CAS 32222-06-3 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Vitamin D₃, 1α, 25-Dihydroxy- - CAS 32222-06-3 - Calbiochem 分析证书

标题	批号
679101	输入批号

参考

参考信息概述
Semizarov, D., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 15412. Hannun, Y.A. 1994. J. Biol. Chem. 269, 3125. Mathieu, C., et al. 1994. Diabetologica 37, 552. Thomasset, M. 1994. Pathol. Biol. 42, 163. Horton, W.E., Jr., et al. 1991. J. Biol. Chem. 266, 24804. Larsen, C.G., et al. 1991. Biochem. Biophys. Res. Commun. 176, 1020. Thavarajah, M., et al. 1991. Biochem. Biophys. Res. Commun. 176, 1189. Wakasugi, M., et al. 1991. Prostaglandins 42, 127. Matsumoto, K., et al. 1990. Biochem. Biophys. Res. Commun. 166, 916. Simpson, R.U., et al. 1989. J. Biol. Chem. 264, 19710. DeLuca, H.F., and Schnoes, H.K. 1983. Annu. Rev. Biochem. 52, 411.

参考信息概述

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	16-August-2021 JSW
Synonyms	1,25-(OH)₂-D₃, Calcitriol
Description	Active hormonal form of vitamin D, formed by the renal 1-hydroxylation of 25-(OH)D₃. Has immunomodulatory properties in vitro and in vivo. Prevents the development of clinical diabetes in NOD mice, which are an animal model of human autoimmune diabetes. Induces reversible hydrolysis of the sphingomyelin cycle and generates ceramide. Stimulates intestinal Ca²⁺ and phosphate transport and mobilizes Ca²⁺ from bone. Involved in cellular differentiation, carcinogenesis, and insulin secretion.
Form	Solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	32222-06-3
RTECS	FZ4645000
Chemical formula	C₂₇H₄₄O₃
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (50 mg/ml) or Ethanol
Storage	Protect from light ≤ -70°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C.
Toxicity	Highly Toxic & Carcinogenic / Teratogenic
Merck USA index	14, 1644
References	Semizarov, D., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 15412. Hannun, Y.A. 1994. J. Biol. Chem. 269, 3125. Mathieu, C., et al. 1994. Diabetologica 37, 552. Thomasset, M. 1994. Pathol. Biol. 42, 163. Horton, W.E., Jr., et al. 1991. J. Biol. Chem. 266, 24804. Larsen, C.G., et al. 1991. Biochem. Biophys. Res. Commun. 176, 1020. Thavarajah, M., et al. 1991. Biochem. Biophys. Res. Commun. 176, 1189. Wakasugi, M., et al. 1991. Prostaglandins 42, 127. Matsumoto, K., et al. 1990. Biochem. Biophys. Res. Commun. 166, 916. Simpson, R.U., et al. 1989. J. Biol. Chem. 264, 19710. DeLuca, H.F., and Schnoes, H.K. 1983. Annu. Rev. Biochem. 52, 411.

种类

Life Science Research > Inhibitors and Biochemicals > Biochemicals > Vitamins, Coenzymes and Cofactors

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