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Indole alkaloid that binds to tubulin, inhibiting formation of microtubules. Depolymerizes microtubules. Induces increase in micronuclei and delays cell cycle progression. Anti-neoplastic agent. Induces apoptosis in human lymphoma cells by disrupting microtubules.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number
677181
Brand Family
Calbiochem®
References
References
Chan, M.W., et al. 1998. Cancer Biochem. Biophys. 16, 347. Hanauske, A.R., et al. 1994. Eur. J. Cancer30A, 1688. Takano, Y., et al. 1993. Pathol. Res. Pract. 189, 187.
Irritating to eyes, respiratory system and skin. May impair fertility. May cause harm to the unborn child.
S Phrase
S: 22-26-36/37/39-45
Do not breathe dust. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code
Ambient Temperature Only
Toxicity
Carcinogenic / Teratogenic
Storage
+2°C to +8°C
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 1 month at 4°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号
GTIN
677181-10MGCN
04055977260601
Documentation
Vincristine Sulfate, Apocynaceae sp. - CAS 2068-78-2 - Calbiochem MSDS
Vincristine Sulfate, Apocynaceae sp. - CAS 2068-78-2 - Calbiochem 分析证书
标题
批号
677181
参考
参考信息概述
Chan, M.W., et al. 1998. Cancer Biochem. Biophys. 16, 347. Hanauske, A.R., et al. 1994. Eur. J. Cancer30A, 1688. Takano, Y., et al. 1993. Pathol. Res. Pract. 189, 187.
数据表
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
14-July-2017 JSW
Description
Indole alkaloid that binds to tubulin, inhibiting the formulation of microtubules. Depolymerizes microtubules. Induces an increase in the micronucleus and delays cell cycle progression. Antineoplastic agent. Induces apoptosis in human lymphoma cells by distributing microtubules.
Form
White solid
CAS number
2068-78-2
RTECS
OH6340000
Chemical formula
C₄₆H₅₆N₄O₁₀ · H₂SO₄
Structure formula
Purity
≥98% by TLC
Solubility
H₂O (20 mg/ml)
Storage
+2°C to +8°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 1 month at 4°C.
Toxicity
Carcinogenic / Teratogenic
Merck USA index
14, 9986
References
Chan, M.W., et al. 1998. Cancer Biochem. Biophys. 16, 347. Hanauske, A.R., et al. 1994. Eur. J. Cancer30A, 1688. Takano, Y., et al. 1993. Pathol. Res. Pract. 189, 187.
