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A dual reuptake inhibitor of serotonin-norepinephrine with strong preference to serotonin (Ki = 82 and 2480 nM for SERT and NET respectively). Also inhibits reuptake of dopamine. Used in studies of depression, ADHD, and stress-related anxiety.
Kaur, J., et al. et al. 2010. J. Pharmacy & Bioallied Sci.2, 22. Aboelwafa, A., et al. 2010. AAPS PharmSciTech.11, 1026. Bernardi, S., et al. 2009. J. Thermal Analysis & Calorimetry.97, 729.
Kaur, J., et al. et al. 2010. J. Pharmacy & Bioallied Sci.2, 22. Aboelwafa, A., et al. 2010. AAPS PharmSciTech.11, 1026. Bernardi, S., et al. 2009. J. Thermal Analysis & Calorimetry.97, 729.
数据表
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
A dual reuptake inhibitor of serotonin-norepinephrine with strong preference to serotonin (Ki = 82 and 2480 nM for SERT and NET respectively). Also inhibits reuptake of dopamine. Used in studies of depression, ADHD, and stress-related anxiety.
Form
White solid
Intert gas (Yes/No)
Packaged under inert gas
CAS number
99300-78-4
Chemical formula
C₁₇H₂₇NO₂·HCl
Structure formula
Purity
≥99% by HPLC
Solubility
DMSO (50 mM) or H₂O (100 mM)
Storage
Protect from light
+2°C to +8°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Standard Handling
References
Kaur, J., et al. et al. 2010. J. Pharmacy & Bioallied Sci.2, 22. Aboelwafa, A., et al. 2010. AAPS PharmSciTech.11, 1026. Bernardi, S., et al. 2009. J. Thermal Analysis & Calorimetry.97, 729.
