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676380 Sigma-AldrichValproic Acid, Sodium Salt - CAS 1069-66-5 - Calbiochem

Valproic Acid, Sodium Salt, CAS 1069-66-5, is a cell-permeable inhibitor of histone deacetylase (IC50 = 400 µM for HDAC1). Inhibits proliferation of human malignant glioma cell lines.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
技术信息
数据表
Data Sheet

同义词: 2-Propylpentanoic Acid, Na

Primary Target: HDAC1

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
1069-66-5	C₈H₁₅O₂Na

价格及供货情况

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Description
Overview	A cell-permeable, short-chained fatty acid that inhibits histone deacetylase (IC₅₀ = 400 µM for HDAC1). Induces differentiation and inhibits proliferation of cell lines derived from human malignant gliomas. At therapeutic levels (0.35 mM - 1.04 mM), causes inositol depletion, inhibits both GSK-3α and -3β, activates ERK pathway and produces neurotropic effects. Has been used as an anti-epileptic agent. Also reported to stimulate peroxisome proliferator-activated receptor (PPAR) activity. Displays a potent teratogenic activity in humans and rodent models.
Catalogue Number	676380
Brand Family	Calbiochem®
Synonyms	2-Propylpentanoic Acid, Na

References
References	Gottlicher, M., et al. 2001. EMBO J. 20, 6969. Knupfer, M.M., et al. 2001. Anticancer Res. 21, 347. Phiel, C.J., et al. 2001. J. Biol. Chem. 276, 36734. Vaden, D.L., et al. 2001. J. Biol. Chem. 276, 15466. Yuan, P.X., et al. 2001. J. Biol. Chem. 276, 31674. Chen, G., et al. 1999. J. Neurochem. 72, 1327.

Product Information
CAS number	1069-66-5
ATP Competitive	N
Form	White solid
Hill Formula	C₈H₁₅O₂Na
Chemical formula	C₈H₁₅O₂Na
Hygroscopic	Hygroscopic
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications
Application	Valproic Acid, Sodium Salt, CAS 1069-66-5, is a cell-permeable inhibitor of histone deacetylase (IC50 = 400 µM for HDAC1). Inhibits proliferation of human malignant glioma cell lines.

Biological Information
Primary Target	HDAC1
Primary Target IC<sub>50</sub>	400 µM
Purity	≥98% by GC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	YV7876000

Safety Information
R Phrase	R: 20/21/22-36/37/38-61 Harmful by inhalation, in contact with skin and if swallowed. Irritating to eyes, respiratory system and skin. May cause harm to the unborn child.
S Phrase	S: 3/7/9-22-36/37/39-45 Keep container tightly closed, in a cool well ventilated place. Do not breathe dust. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Harmful & Carcinogenic / Teratogenic
Storage	+2°C to +8°C
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
676380-5GMCN	04055977183566

Documentation

Valproic Acid, Sodium Salt - CAS 1069-66-5 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Valproic Acid, Sodium Salt - CAS 1069-66-5 - Calbiochem 分析证书

标题	批号
676380	输入批号

参考

参考信息概述
Gottlicher, M., et al. 2001. EMBO J. 20, 6969. Knupfer, M.M., et al. 2001. Anticancer Res. 21, 347. Phiel, C.J., et al. 2001. J. Biol. Chem. 276, 36734. Vaden, D.L., et al. 2001. J. Biol. Chem. 276, 15466. Yuan, P.X., et al. 2001. J. Biol. Chem. 276, 31674. Chen, G., et al. 1999. J. Neurochem. 72, 1327.

技术信息

标题
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数据表

标题
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数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	27-April-2020 JSW
Synonyms	2-Propylpentanoic Acid, Na
Description	A cell-permeable, short-chained fatty acid that inhibits histone deacetylase activity (IC₅₀ = 400 µM for HDAC1). Induces differentiation and inhibits proliferation of cell lines derived from human malignant gliomas. At therapeutic levels (350 µM-1.04 mM), causes inositol depletion, inhibits both GSK-3α and -3β, activates the ERK pathway, and produces neurotropic effects. Has been used as an anti-epileptic agent. Also reported to stimulate peroxisome proliferator-activated receptor (PPAR) activity. Displays a potent teratogenic activity in humans and rodent models.
Form	White solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	1069-66-5
RTECS	YV7876000
Chemical formula	C₈H₁₅O₂Na
Structure formula
Purity	≥98% by GC
Solubility	H₂O (50 mg/ml)
Storage	+2°C to +8°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Harmful & Carcinogenic / Teratogenic
Merck USA index	14, 9913
References	Gottlicher, M., et al. 2001. EMBO J. 20, 6969. Knupfer, M.M., et al. 2001. Anticancer Res. 21, 347. Phiel, C.J., et al. 2001. J. Biol. Chem. 276, 36734. Vaden, D.L., et al. 2001. J. Biol. Chem. 276, 15466. Yuan, P.X., et al. 2001. J. Biol. Chem. 276, 31674. Chen, G., et al. 1999. J. Neurochem. 72, 1327.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Cell Cycle/Cell Division > Histone Acetylase and Deacetylase Inhibitors

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