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672315 Sigma-AldrichUrsolic Acid - CAS 77-52-1 - Calbiochem

A cell-permeable plant-derived pentacyclic triterpene acid that displays anti-inflammatory, immunomodulatory, and antitumor activities.

Ursolic Acid - CAS 77-52-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: 3β-Hydroxy-urs-12-en-28-oic acid, CG7, PTPN2/TCPTP Inhibitor II, SHP2 Inhibitor IV, PTP1B Inhibitor VII, PTP Inhibitor XXVII

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
77-52-1	C₃₀H₄₈O₃

价格及供货情况

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Description
Overview	A cell-permeable plant-derived pentacyclic triterpene acid that displays anti-inflammatory, immunomodulatory, and antitumor activities. Shown to inhibit the phosphatase activity of SHP2, PTP1B, and TCPTP (IC₅₀ = 2.73, 3.08 and 3.33 µM, respectively) as well as induce IR autophosphorylation independent of its phosphatase inhibitory activity. Ursolic acid is also reported to inhibit NF-κB and STAT3 pathway activation in cancer cultures, resulting in enhanced sensitivity to chemotherapy agents and apoptotic cell death.
Catalogue Number	672315
Brand Family	Calbiochem®
Synonyms	3β-Hydroxy-urs-12-en-28-oic acid, CG7, PTPN2/TCPTP Inhibitor II, SHP2 Inhibitor IV, PTP1B Inhibitor VII, PTP Inhibitor XXVII

References
References	Li, Y., et al. 2010. Int. J. Cancer 127, 462. Pathak, A.K., et al. 2007. Mol. Cancer Res. 5, 943. Jung, S.H., et al. 2007. Biochem. J. 403, 243. Zhang, W., et al. 2006. Biochim. Biophys. Acta 1760, 1505. Shishodia, S., et al. 2003. Cancer Res. 63, 4375.

Product Information
CAS number	77-52-1
Form	White powder
Hill Formula	C₃₀H₄₈O₃
Chemical formula	C₃₀H₄₈O₃
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	≥90% by GC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
672315-50MGCN	04055977184136

Documentation

Ursolic Acid - CAS 77-52-1 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Ursolic Acid - CAS 77-52-1 - Calbiochem 分析证书

标题	批号
672315	输入批号

参考

参考信息概述
Li, Y., et al. 2010. Int. J. Cancer 127, 462. Pathak, A.K., et al. 2007. Mol. Cancer Res. 5, 943. Jung, S.H., et al. 2007. Biochem. J. 403, 243. Zhang, W., et al. 2006. Biochim. Biophys. Acta 1760, 1505. Shishodia, S., et al. 2003. Cancer Res. 63, 4375.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	23-December-2023 JSW
Synonyms	3β-Hydroxy-urs-12-en-28-oic acid, CG7, PTPN2/TCPTP Inhibitor II, SHP2 Inhibitor IV, PTP1B Inhibitor VII, PTP Inhibitor XXVII
Description	A cell-permeable plant-derived pentacyclic triterpene acid that displays anti-inflammatory, immunomodulatory, and antitumor activities. Shown to inhibit the phosphatase activity of SHP2, PTP1B, and TCPTP (IC₅₀ = 2.73, 3.08 and 3.33 µM, respectively) as well as induce IR autophosphorylation independent of its phosphatase inhibitory activity. Ursolic acid is also reported to inhibit NF-κB and STAT3 pathway activation in cancer cultures, resulting in enhanced sensitivity to chemotherapy agents and apoptotic cell death.
Form	White powder
Intert gas (Yes/No)	Packaged under inert gas
CAS number	77-52-1
Chemical formula	C₃₀H₄₈O₃
Structure formula
Purity	≥90% by GC
Solubility	Dimethylformamide or DMSO (50 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Standard Handling
References	Li, Y., et al. 2010. Int. J. Cancer 127, 462. Pathak, A.K., et al. 2007. Mol. Cancer Res. 5, 943. Jung, S.H., et al. 2007. Biochem. J. 403, 243. Zhang, W., et al. 2006. Biochim. Biophys. Acta 1760, 1505. Shishodia, S., et al. 2003. Cancer Res. 63, 4375.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Phosphatase Inhibitors

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