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662035 Sigma-AldrichU-73122 - CAS 112648-68-7 - Calbiochem

U-73122, CAS 112648-68-7, inhibits agonist-induced phospholipase C activation (IC50 = 1-2.1 µM) in human platelets and neutrophils.

U-73122 - CAS 112648-68-7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet
Citations

同义词: 1-[6-((17β-3-Methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl]-1H-pyrrole-2,5-dione

Primary Target: Agonist-induced phospholipase C activation

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
112648-68-7	C₂₉H₄₀N₂O₃

价格及供货情况

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Description
Overview	A potent, selective, and cell-permeable inhibitor C-type phosphatidylinositol-specific phospholipases. Inhibits agonist-induced phospholipase C activation (IC₅₀ = 1-2.1 µM) in human platelets and neutrophils. Inhibits ET-1 and parathyroid hormone-induced Ca²⁺ transients (IC₅₀ = 800 nM and 500 nM, respectively). Also inhibits agonist-induced down-regulation of muscarinic receptors in SK-N-SH neuroblastoma cells. Acts as a potent inhibitor of human polymorphonuclear neutrophil adhesion on biological surfaces (IC₅₀ = 50 nM). Reported to abolish T lymphoma cell invasion into fibroblast monolayers.
Catalogue Number	662035
Brand Family	Calbiochem®
Synonyms	1-[6-((17β-3-Methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl]-1H-pyrrole-2,5-dione

References
References	Stam, J.C., et al. 1998. EMBO J. 17, 4066. Smith, R.J., et al. 1996. J. Pharmacol. Exp. Ther. 278, 320. Tatrai, A., et al. 1994. Biochim. Biophys. Acta 1224, 595. Wang, X.D., et al. 1994. Biochim. Biophys. Acta 1223, 101. Bleasdale, J.E., and Fisher, S.K. 1993. Neuroprotocols: A Companion to Methods in Neurosci. 3, 125. Wu, H., et al. 1992. Biochemistry 31, 3370. Yule, D.I., and Williams, J.A. 1992. J. Biol. Chem. 267, 13830. Thompson, A.K., et al. 1991. J. Biol. Chem. 266, 23856.

References

Stam, J.C., et al. 1998. EMBO J. 17, 4066.
Smith, R.J., et al. 1996. J. Pharmacol. Exp. Ther. 278, 320.
Tatrai, A., et al. 1994. Biochim. Biophys. Acta 1224, 595.
Wang, X.D., et al. 1994. Biochim. Biophys. Acta 1223, 101.
Bleasdale, J.E., and Fisher, S.K. 1993. Neuroprotocols: A Companion to Methods in Neurosci. 3, 125.
Wu, H., et al. 1992. Biochemistry 31, 3370.
Yule, D.I., and Williams, J.A. 1992. J. Biol. Chem. 267, 13830.
Thompson, A.K., et al. 1991. J. Biol. Chem. 266, 23856.

Product Information
CAS number	112648-68-7
ATP Competitive	N
Form	Off-white solid
Hill Formula	C₂₉H₄₀N₂O₃
Chemical formula	C₂₉H₄₀N₂O₃
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications
Application	U-73122, CAS 112648-68-7, inhibits agonist-induced phospholipase C activation (IC50 = 1-2.1 µM) in human platelets and neutrophils.

Biological Information
Primary Target	Agonist-induced phospholipase C activation
Primary Target IC<sub>50</sub>	1-2.1 µM against agonist-induced phospholipase C activation in human platelets and neutrophils; 800 nM and 500 nM, respectively, against ET-1 and parathyroid hormone-induced Ca2+ transients; 50 nM against human polymorphonuclear neutrophil adhesion
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information
R Phrase	R: 36/37/38 Irritating to eyes, respiratory system and skin.
S Phrase	S: 26-36 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing.

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Irritant
Storage	+15°C to +30°C
Do not freeze	Ok to freeze
Special Instructions	Unstable in DMSO and ethanol; reconstitute in anhydrous DMSO or ethanol just prior to use. Following reconstitution in anhydrous chloroform, aliquot into single use volumes, evaporate to dryness under a stream of nitrogen, and freeze (-20°C. Dried aliquots are stable for up to 6 months at -20°C. ); Reconstitute dried aliquots in anhydrous DMSO or anhydrous ethanol just prior to use.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
662035-5MGCN	07790788052256

Documentation

U-73122 - CAS 112648-68-7 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

U-73122 - CAS 112648-68-7 - Calbiochem 分析证书

标题	批号
662035	输入批号

参考

参考信息概述
Stam, J.C., et al. 1998. EMBO J. 17, 4066. Smith, R.J., et al. 1996. J. Pharmacol. Exp. Ther. 278, 320. Tatrai, A., et al. 1994. Biochim. Biophys. Acta 1224, 595. Wang, X.D., et al. 1994. Biochim. Biophys. Acta 1223, 101. Bleasdale, J.E., and Fisher, S.K. 1993. Neuroprotocols: A Companion to Methods in Neurosci. 3, 125. Wu, H., et al. 1992. Biochemistry 31, 3370. Yule, D.I., and Williams, J.A. 1992. J. Biol. Chem. 267, 13830. Thompson, A.K., et al. 1991. J. Biol. Chem. 266, 23856.

参考信息概述

引用

标题

M. Keith Wilkerson, et al. (2006) Inositol triphosphate receptor calcium release is required for cerebral artery smooth muscle cell proliferation. American Journal of Physiology Heart and Circulatory Physiology 290, H240-H247.

Martha E. O'Donnnell, et al. (2005) Arginine Vasopressin Stimulation of Cerebral Microvascular Endothelial Cell Na-K-Cl Cotransporter Activity is V1 Receptor and [Ca] Dependent. American Journal of Physiology Cell Physiology 289, C283-C292.

Di Zhang, et al. (2005) Strontium Promotes Calcium Oscillations in Mouse Meiotic Oocytes and Early Embryos Through InsP3 Receptors, and Requires Activation of Phopsholipase and the Synertistic Action of InsP3. Human Reproduction in press,.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	18-August-2017 JSW
Synonyms	1-[6-((17β-3-Methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl]-1H-pyrrole-2,5-dione
Description	A potent, selective, and cell-permeable inhibitor C-type phosphatidylinositol-specific phospholipases. Inhibits agonist-induced phospholipase C activation (IC₅₀ = 1-2.1 µM) in human platelets and neutrophils. Inhibits ET-1 and parathyroid hormone induced Ca2⁺ transients (IC₅₀ = 800 nM and 500 nM, respectively). Also inhibits agonist-induced down-regulation of muscarinic receptors in SK-N-SH neuroblastoma cells. Acts as a potent inhibitor of human polymorphonuclear neutrophil adhesion on biological surfaces (IC₅₀ = 50 nM). Abolishes T lymphoma cell invasion into fibroblast monolayers.
Form	Off-white solid
CAS number	112648-68-7
Chemical formula	C₂₉H₄₀N₂O₃
Structure formula
Purity	≥98% by HPLC
Solubility	Anhydrous Chloroform (3 mg/ml), Anhydrous DMSO (1 mg/ml), or Anhydrous Ethanol (500 µg/ml). The use of anhydrous solvents is critical for the solubility of the compound; the presence of moisture in the solvent will lower the solubility of the compound.
Storage	+15°C to +30°C
Do Not Freeze	Ok to freeze
Special Instructions	Unstable in DMSO and ethanol; reconstitute in anhydrous DMSO or ethanol just prior to use. Following reconstitution in anhydrous chloroform, aliquot into single use volumes, evaporate to dryness under a stream of nitrogen, and freeze (-20°C. Dried aliquots are stable for up to 6 months at -20°C. ); Reconstitute dried aliquots in anhydrous DMSO or anhydrous ethanol just prior to use.
Toxicity	Irritant
References	Stam, J.C., et al. 1998. EMBO J. 17, 4066. Smith, R.J., et al. 1996. J. Pharmacol. Exp. Ther. 278, 320. Tatrai, A., et al. 1994. Biochim. Biophys. Acta 1224, 595. Wang, X.D., et al. 1994. Biochim. Biophys. Acta 1223, 101. Bleasdale, J.E., and Fisher, S.K. 1993. Neuroprotocols: A Companion to Methods in Neurosci. 3, 125. Wu, H., et al. 1992. Biochemistry 31, 3370. Yule, D.I., and Williams, J.A. 1992. J. Biol. Chem. 267, 13830. Thompson, A.K., et al. 1991. J. Biol. Chem. 266, 23856.
Citation	M. Keith Wilkerson, et al. (2006) Inositol triphosphate receptor calcium release is required for cerebral artery smooth muscle cell proliferation. American Journal of Physiology Heart and Circulatory Physiology 290, H240-H247. Martha E. O'Donnnell, et al. (2005) Arginine Vasopressin Stimulation of Cerebral Microvascular Endothelial Cell Na-K-Cl Cotransporter Activity is V1 Receptor and [Ca] Dependent. American Journal of Physiology Cell Physiology 289, C283-C292. Di Zhang, et al. (2005) Strontium Promotes Calcium Oscillations in Mouse Meiotic Oocytes and Early Embryos Through InsP3 Receptors, and Requires Activation of Phopsholipase and the Synertistic Action of InsP3. Human Reproduction in press,.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Lipid Signaling Inhibitors > Phospholipase Inhibitors

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