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648485 Sigma-AldrichTrpA1 Antagonist, HC-030031 - CAS 349085-38-7 - Calbiochem

The TrpA1 Antagonist, HC-030031, also referenced under CAS 349085-38-7, controls the biological activity of TrpA1. This small molecule/inhibitor is primarily used for Neuroscience applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: HC-030031

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
349085-38-7	C₁₈H₂₁N₅O₃

价格及供货情况

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Description
Overview	A cell-permeable and selective TRPA1 antagonist that reversibly antagonizes AITC- and formalin-evoked calcium influx (IC50 = 6.2 µM and 5.3 µ M, respectively), and blocks AITC- and formalin-induced inward and outward currents in TRPA1-expressing HEK293 cells in a patch-clamp assay. It demonstrates activity towards rat and mouse TRPA1 orthologues, but does not block currents mediated by TRPV1, TRPV3, TRPV4, hERG, or NaV1.2 channels. This compound is also shown to block TRPA1 activation induced by formalin in cultured rat DRG neurons, and attenuate pain-related responses to formalin in rats (300 mg/kg, i.p.), in vivo.
Catalogue Number	648485
Brand Family	Calbiochem®
Synonyms	HC-030031

References
References	Taylor-Clark, T., et al. 2008. Mol. Pharmacol. 73, 274. McNamara, C., et al. 2007. Proc. Natl. Acad. Sci. U S A. 104, 13525.

Product Information
CAS number	349085-38-7
Form	White solid
Hill Formula	C₁₈H₂₁N₅O₃
Chemical formula	C₁₈H₂₁N₅O₃
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	≥98% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
648485-10MGCN	04055977185058

Documentation

TrpA1 Antagonist, HC-030031 - CAS 349085-38-7 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

TrpA1 Antagonist, HC-030031 - CAS 349085-38-7 - Calbiochem 分析证书

标题	批号
648485	输入批号

参考

参考信息概述
Taylor-Clark, T., et al. 2008. Mol. Pharmacol. 73, 274. McNamara, C., et al. 2007. Proc. Natl. Acad. Sci. U S A. 104, 13525.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	14-May-2012 JSW
Synonyms	HC-030031
Description	A cell-permeable and selective TRPA1 antagonist that reversibly antagonizes AITC- and formalin-evoked calcium influx (IC50 = 6.2 µM and 5.3 µ M, respectively), and blocks AITC- and formalin-induced inward and outward currents in TRPA1-expressing HEK293 cells in a patch-clamp assay. It demonstrates activity towards rat and mouse TRPA1 orthologues, but does not block currents mediated by TRPV1, TRPV3, TRPV4, hERG, or NaV1.2 channels. This compound is also shown to block TRPA1 activation induced by formalin in cultured rat DRG neurons, and attenuate pain-related responses to formalin in rats (300 mg/kg, i.p.), in vivo.
Form	White solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	349085-38-7
Chemical formula	C₁₈H₂₁N₅O₃
Structure formula
Purity	≥98% by HPLC
Solubility	DMSO (50 mg/ml; clear, colorless solution)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Taylor-Clark, T., et al. 2008. Mol. Pharmacol. 73, 274. McNamara, C., et al. 2007. Proc. Natl. Acad. Sci. U S A. 104, 13525.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Neurochemicals > Channel Blockers > Calcium Channel Blockers

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