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506300 Sigma-AldrichTrkB Agonist, 7,8-Dihydroxyflavone - CAS 38183-03-8 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
参考
Data Sheet

同义词: 7,8-DHF

Primary Target: TrkB

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
38183-03-8	C₁₅H₁₀O₄

价格及供货情况

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Description
Overview	A cell permeable flavone based compound with neurotrophic and neuroprotective properties. Mimicks the action of Brain Derived Neurotrophic Factor (BDNF) and acts as a TrkB receptor agonist. Due to its lipophilic nature, it can cross the blood-brain barrier. Binds to the extra cellular domain of TrkB with high affinity and promotes its dimerization and autophosphorylation. Potentiates TrkB, but not TrkA, signaling in mouse brain slices. Its neurotropic effects are abolished in the presence of K252a. Suppresses apoptosis in human and rodent neurons and in stably transfected TrkB murine cell line T48 (EC₅₀ = 35 nM). Selectively reduces the basal GABAergic transmission due to its suppressive effect on presynaptic GABA release. However, it does not affect glutamatergic transmission.
Catalogue Number	506300
Brand Family	Calbiochem®
Synonyms	7,8-DHF

References
References	Ren, Q., et al. 2013. Pharm. Biochem. Behav. 106, 124. Marongiu, D., et al. 2013. Eur. J. Pharmacol. 709, 64. Jang, S., et al. 2010. PNAS 107, 2687.

Product Information
CAS number	38183-03-8
Form	Yellow powder
Hill Formula	C₁₅H₁₀O₄
Chemical formula	C₁₅H₁₀O₄
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	TrkB
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
5.06300.0001	04055977243222

Documentation

TrkB Agonist, 7,8-Dihydroxyflavone - CAS 38183-03-8 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

参考

参考信息概述
Ren, Q., et al. 2013. Pharm. Biochem. Behav. 106, 124. Marongiu, D., et al. 2013. Eur. J. Pharmacol. 709, 64. Jang, S., et al. 2010. PNAS 107, 2687.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	22-November-2013 JSW
Synonyms	7,8-DHF
Description	A cell permeable flavone based compound with neurotrophic and neuroprotective properties. Mimicks the action of Brain Derived Neurotrophic Factor (BDNF) and acts as a TrkB receptor agonist. Due to its lipophilic nature, it can cross the blood-brain barrier. Binds to the extra cellular domain of TrkB with high affinity and promotes its dimerization and autophosphorylation. Potentiates TrkB, but not TrkA, signaling in mouse brain slices. Its neurotropic effects are abolished in the presence of K252a. Suppresses apoptosis in human and rodent neurons and in stably transfected TrkB murine cell line T48 (EC₅₀ = 35 nM). Selectively reduces the basal GABAergic transmission due to its suppressive effect on presynaptic GABA release. However, it does not affect glutamatergic transmission.
Form	Yellow powder
Intert gas (Yes/No)	Packaged under inert gas
CAS number	38183-03-8
Chemical formula	C₁₅H₁₀O₄
Structure formula
Purity	≥98% by HPLC
Solubility	DMSO (100 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Ren, Q., et al. 2013. Pharm. Biochem. Behav. 106, 124. Marongiu, D., et al. 2013. Eur. J. Pharmacol. 709, 64. Jang, S., et al. 2010. PNAS 107, 2687.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Neurochemicals > Other Neurochemicals

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