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645900 Sigma-AldrichTriptolide, Tripterygium wilfordii - CAS 38748-32-2 - Calbiochem

A novel diterpene triepoxide isolated from the Chinese herb Tripterygium wilfordii that acts as a potent immunosuppressant and anti-inflammatory agent.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: PG490

Primary Target: Activate DEVD-cleaving caspases

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
38748-32-2	C₂₀H₂₄O₆

价格及供货情况

产品目录编号	库存情况	包装	数量 / 包装	价格	数量
645900-1MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	塑胶安瓿;塑胶针药瓶	1 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹
645900-5MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	塑胶安瓿;塑胶针药瓶	5 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹

Description
Overview	A novel diterpene triepoxide isolated from the Chinese herb Tripterygium wilfordii that acts as a potent immunosuppressant and anti-inflammatory agent. Induces apoptosis in tumor cells by activating DEVD-cleaving caspases. Sensitizes tumor cells to TNF-α-induced apoptosis, and inhibits TNF-α-induced activation of NF-κB. Also inhibits T cell IL-2 expression at the level of purine-box/nuclear factor of activated T cells and NF-κB transcriptional activation. Also reported to inhibit mitogen activated protein kinase phosphatase-1 (MKP-1).
Catalogue Number	645900
Brand Family	Calbiochem®
Synonyms	PG490

References
References	Zhao, Q., et al. 2005. J. Biol. Chem. 280, 8101. Shepherd, E., et al. 2004. J. Biol. Chem. 279, 54023. Chan, M.A., et al. 1999. Phytother. Res. 13, 464. Lee, K.Y., et al. 1999. J. Biol. Chem. 274, 13451. Qiu, D., et al. 1999. J. Biol. Chem. 274, 13443. Yang, Y., et al. 1998. Immunopharmacology 40, 139.

Product Information
CAS number	38748-32-2
ATP Competitive	N
Form	Off-white solid
Hill Formula	C₂₀H₂₄O₆
Chemical formula	C₂₀H₂₄O₆
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Activate DEVD-cleaving caspases
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	N

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	YK7751000

Safety Information
R Phrase	R: 20/21/22-40 Harmful by inhalation, in contact with skin and if swallowed. Limited evidence of a carcinogenic effect.
S Phrase	S: 22-36 Do not breathe dust. Wear suitable protective clothing.

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Harmful & Carcinogenic / Teratogenic
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 weeks at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
645900-1MGCN	04055977262193
645900-5MGCN	04055977262209

Documentation

Triptolide, Tripterygium wilfordii - CAS 38748-32-2 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Triptolide, Tripterygium wilfordii - CAS 38748-32-2 - Calbiochem 分析证书

标题	批号
645900	输入批号

参考

参考信息概述
Zhao, Q., et al. 2005. J. Biol. Chem. 280, 8101. Shepherd, E., et al. 2004. J. Biol. Chem. 279, 54023. Chan, M.A., et al. 1999. Phytother. Res. 13, 464. Lee, K.Y., et al. 1999. J. Biol. Chem. 274, 13451. Qiu, D., et al. 1999. J. Biol. Chem. 274, 13443. Yang, Y., et al. 1998. Immunopharmacology 40, 139.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	08-May-2009 RFH
Synonyms	PG490
Description	A novel diterpene triepoxide isolated from the Chinese herb Tripterygium wilfordii that acts as a potent immunosuppressant and anti-inflammatory agent. Induces apoptosis in tumor cells, sensitizes tumor cells to TNF-α-induced activation of NF-κB. Also inhibits IL-2 expression in activated T-cells at the level of purine-box/nuclear factor and NF-κB transcriptional activation. Also reported to inhibit mitogen activated protein kinase phosphatase-1 (MKP-1). Reported to induce apoptosis by activating DEVD-cleaving caspases.
Form	Off-white solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	38748-32-2
RTECS	YK7751000
Chemical formula	C₂₀H₂₄O₆
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (20 mg/ml)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 weeks at -20°C.
Toxicity	Harmful & Carcinogenic / Teratogenic
References	Zhao, Q., et al. 2005. J. Biol. Chem. 280, 8101. Shepherd, E., et al. 2004. J. Biol. Chem. 279, 54023. Chan, M.A., et al. 1999. Phytother. Res. 13, 464. Lee, K.Y., et al. 1999. J. Biol. Chem. 274, 13451. Qiu, D., et al. 1999. J. Biol. Chem. 274, 13443. Yang, Y., et al. 1998. Immunopharmacology 40, 139.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Immunomodulators

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