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616373 Sigma-AldrichTpl2 Kinase Inhibitor - CAS 871307-18-5 - Calbiochem

Tpl2 Kinase Inhibitor, CAS 871307-18-5, is a cell-permeable, potent, reversible, and ATP-competitive inhibitor of Tpl2 kinase (IC50 = 50 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
Data Sheet
Posters

同义词: 4-(3-Chloro-4-fluorophenylamino)-6-(pyridin-3-yl-methylamino)-3-cyano-[1,7]-naphthyridine

Primary Target: Tpl2 Kinase

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
871307-18-5	C₂₁H₁₄ClFN₆

价格及供货情况

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Description
Overview	A cell-permeable naphthyridine compound that acts as a potent, reversible, and ATP-competitive inhibitor of Tpl2 kinase (IC₅₀ = 50 nM). Displays significant selectivity over other related kinases (IC₅₀ = 5, >40, 110, 180, >400 and >400 µM for EGFR, MEK, MK2, p38, Src, and PKC, respectively). Shown to inhibit LPS-induced TNF-α production both from primary human monocytes and in whole blood (IC₅₀ = 700 nM and 8.5 µM, respectively).
Catalogue Number	616373
Brand Family	Calbiochem®
Synonyms	4-(3-Chloro-4-fluorophenylamino)-6-(pyridin-3-yl-methylamino)-3-cyano-[1,7]-naphthyridine

References
References	Gavrin, L.K., et al. 2005. Bioorg. Med. Chem. Lett. 15, 5288.

Product Information
CAS number	871307-18-5
ATP Competitive	Y
Form	Yellow solid
Hill Formula	C₂₁H₁₄ClFN₆
Chemical formula	C₂₁H₁₄ClFN₆
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications
Application	Tpl2 Kinase Inhibitor, CAS 871307-18-5, is a cell-permeable, potent, reversible, and ATP-competitive inhibitor of Tpl2 kinase (IC50 = 50 nM).

Biological Information
Primary Target	Tpl2 Kinase
Primary Target IC<sub>50</sub>	50 nM against Tpl2 kinase
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information
R Phrase	R: 36/37/38 Irritating to eyes, respiratory system and skin.
S Phrase	S: 26-36 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing.

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Irritant
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
616373-1MGCN	04055977186239

Documentation

Tpl2 Kinase Inhibitor - CAS 871307-18-5 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Tpl2 Kinase Inhibitor - CAS 871307-18-5 - Calbiochem 分析证书

标题	批号
616373	输入批号

参考

参考信息概述
Gavrin, L.K., et al. 2005. Bioorg. Med. Chem. Lett. 15, 5288.

小册子

标题
Pathways and Biomarkers of Toll-like Receptor (TLR) Signaling

海报

标题
Human Kinome & InhibitorSelect™ Libraries

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	05-October-2007 JSW
Synonyms	4-(3-Chloro-4-fluorophenylamino)-6-(pyridin-3-yl-methylamino)-3-cyano-[1,7]-naphthyridine
Description	A cell-permeable naphthyridine compound that acts as a potent, reversible, and ATP-competitive inhibitor of Tpl2 kinase (IC₅₀ = 50 nM). Displays significant selectivity over other related kinases (IC₅₀ = 5, >40, 110, 180, >400 and >400 µM for EGFR, MEK, MK2, p38, Src, and PKC, respectively). Shown to inhibit LPS-induced TNF-α production both from primary human monocytes and in whole blood (IC₅₀ = 700 nM and 8.5 µM, respectively).
Form	Yellow solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	871307-18-5
Chemical formula	C₂₁H₁₄ClFN₆
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (10 mg/ml)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Irritant
References	Gavrin, L.K., et al. 2005. Bioorg. Med. Chem. Lett. 15, 5288.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > MAP Kinase Inhibitors

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