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			96-Well Plate

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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

586005 Sigma-AldrichThapsigargin - CAS 67526-95-8 - Calbiochem

Thapsigargin, CAS 67526-95-8, is a cell-permeable, tumor-promoting sesquiterpene lactone that releases calcium by non-competitvley inhibiting endoplasmic reticular Ca2+-ATPase (IC₅₀ = 4-13 nM).

Thapsigargin - CAS 67526-95-8 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
Data Sheet

Primary Target: endoplasmic reticular Ca²⁺ ATPase

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
67526-95-8	C₃₄H₅₀O₁₂

价格及供货情况

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Description
Overview	A cell-permeable tumor-promoting sesquiterpene lactone that releases Ca²⁺ by inhibiting endoplasmic reticular Ca²⁺-ATPase (IC₅₀ = 4-13 nM). Does not increase inositol phosphates and has no significant effect on protein kinase C. Increases Ca²⁺-dependent Na⁺ influx in human platelets in a dose-dependent manner. Induces apoptosis in rat thymocytes and in human hepatoma cells. Shown to induce apoptosis in alveolar rhabdomyosarcoma cells by elevating Akt-stimulated PAX3-FOXO1 phosphorylation and promoting its proteasomal degradation.
Catalogue Number	586005
Brand Family	Calbiochem®

References
References	Jothi, M., et al. 2013. Mol. Cancer Ther. In press. Won, J.G. and Orth, D.N. 1995. Endocrinology 136, 5399. Tepel, M., et al. 1994. Biochim. Biophys. Acta 1220, 248. Begum, N., et al. 1993. J. Biol. Chem. 268, 3352. Low, A.M., et al. 1993. Eur. J. Pharmacol. 230, 53. Tsukamoto, A. and Karneko, Y. 1993. Cell. Biol. Int. 17, 969. Wong, W.L., et al. 1993. Biochem. J. 289, 71. Glennon, M.C., et al. 1992. J. Biol. Chem. 267, 25568. Xu, Y., et al. 1992. J. Neurochem. 59, 2224. Mason, M.J., et al. 1991. J. Biol. Chem. 266, 20856. Thastrup, O., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 2466.

References

Jothi, M., et al. 2013. Mol. Cancer Ther. In press.
Won, J.G. and Orth, D.N. 1995. Endocrinology 136, 5399.
Tepel, M., et al. 1994. Biochim. Biophys. Acta 1220, 248.
Begum, N., et al. 1993. J. Biol. Chem. 268, 3352.
Low, A.M., et al. 1993. Eur. J. Pharmacol. 230, 53.
Tsukamoto, A. and Karneko, Y. 1993. Cell. Biol. Int. 17, 969.
Wong, W.L., et al. 1993. Biochem. J. 289, 71.
Glennon, M.C., et al. 1992. J. Biol. Chem. 267, 25568.
Xu, Y., et al. 1992. J. Neurochem. 59, 2224.
Mason, M.J., et al. 1991. J. Biol. Chem. 266, 20856.
Thastrup, O., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 2466.

Product Information
CAS number	67526-95-8
ATP Competitive	N
Form	Colorless solid
Hill Formula	C₃₄H₅₀O₁₂
Chemical formula	C₃₄H₅₀O₁₂
Reversible	N
Structure formula Image
Quality Level	MQ200

Applications

Biological Information
Primary Target	endoplasmic reticular Ca²⁺ ATPase
Primary Target IC<sub>50</sub>	4-13 nM against endoplasmic reticular Ca2+-ATPase
Purity	≥97% by TLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information
R Phrase	R: 36/37/38-42 Irritating to eyes, respiratory system and skin. May cause sensitization by inhalation.
S Phrase	S: 36/37/39-26 Wear suitable protective clothing, gloves and eye/face protection. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Irritant
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 2-3 months at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
586005-1MGCN	04055977265026

Documentation

Thapsigargin - CAS 67526-95-8 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Thapsigargin - CAS 67526-95-8 - Calbiochem 分析证书

标题	批号
586005	输入批号

参考

参考信息概述
Jothi, M., et al. 2013. Mol. Cancer Ther. In press. Won, J.G. and Orth, D.N. 1995. Endocrinology 136, 5399. Tepel, M., et al. 1994. Biochim. Biophys. Acta 1220, 248. Begum, N., et al. 1993. J. Biol. Chem. 268, 3352. Low, A.M., et al. 1993. Eur. J. Pharmacol. 230, 53. Tsukamoto, A. and Karneko, Y. 1993. Cell. Biol. Int. 17, 969. Wong, W.L., et al. 1993. Biochem. J. 289, 71. Glennon, M.C., et al. 1992. J. Biol. Chem. 267, 25568. Xu, Y., et al. 1992. J. Neurochem. 59, 2224. Mason, M.J., et al. 1991. J. Biol. Chem. 266, 20856. Thastrup, O., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 2466.

参考信息概述

小册子

标题
Caspases and other Apoptosis Related Tools Brochure

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	11-October-2013 JSW
Description	A cell-permeable tumor-promoting sesquiterpene lactone that releases Ca²⁺ by inhibiting endoplasmic reticular Ca²⁺-ATPase. Does not increase inositol phosphates and has no significant effect on protein kinase C. Increases Ca²⁺-dependent Na⁺ influx in human platelets in a dose-dependent manner. Activates apoptosis in rat thymocytes and induces apoptosis in human hepatoma cells. Shown to induce apoptosis in alveolar rhabdomyosarcoma cells by elevating Akt-stimulated PAX3-FOXO1 phosphorylation and promoting its proteasomal degradation.
Form	Colorless solid
CAS number	67526-95-8
Chemical formula	C₃₄H₅₀O₁₂
Structure formula
Purity	≥97% by TLC
Solubility	DMSO (>1 mg/ml) or ethanol (5 mg/ml)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 2-3 months at -20°C.
Toxicity	Irritant
References	Jothi, M., et al. 2013. Mol. Cancer Ther. In press. Won, J.G. and Orth, D.N. 1995. Endocrinology 136, 5399. Tepel, M., et al. 1994. Biochim. Biophys. Acta 1220, 248. Begum, N., et al. 1993. J. Biol. Chem. 268, 3352. Low, A.M., et al. 1993. Eur. J. Pharmacol. 230, 53. Tsukamoto, A. and Karneko, Y. 1993. Cell. Biol. Int. 17, 969. Wong, W.L., et al. 1993. Biochem. J. 289, 71. Glennon, M.C., et al. 1992. J. Biol. Chem. 267, 25568. Xu, Y., et al. 1992. J. Neurochem. 59, 2224. Mason, M.J., et al. 1991. J. Biol. Chem. 266, 20856. Thastrup, O., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 2466.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > ATPase/GTPase Inhibitors > ATPase Inhibitors

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