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508578 Sigma-AldrichTSPO Agonist, Ro5-4864 - CAS 14439-61-3 - Calbiochem

A 4'-chloro derivative of diazepam that lacks affinity for GABA-A receptors, but can serve as a ligand for the peripheral benzodiazepine receptor.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
参考
Data Sheet

同义词: 4ʹ-chlorodiazepam, TSPO Activator I, Mitochondrial Translocator Protein Activator I, Ro54864

Primary Target: TSPO

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
14439-61-3	C₁₆H₁₂Cl₂N₂O

价格及供货情况

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Description
Overview	A 4′-chloro derivative of diazepam that lacks affinity for GABA-A receptors, but can serve as a ligand for the peripheral benzodiazepine receptor. Acts as an agonist for the 18 kDa translocator protein (TSPO) on the outer mitochondrial membrane (K_d = 4.4 nM). Diminishes the accumulation of β-amyloid peptides in the CA1 hippocampal region of gonadectomized (GDX) mice and in triple transgenic Alzheimer′s disease murine models (3xTgAD). However, it does not affect tau phosphorylation events as assessed by AT8 immunoreactivity. Also shown to reduce GFAP ionized calcium binding adaptor molecule-1 (IBA-1) in the 3xTgAD mice. Reported to increase testosterone and progesterone levels in GDX mice without affecting other steroid hormones. However, it does not have a significant effect on the levels of these hormones in aged 3xTgAD mice. In combination with another mitochondria targeting molecule, lonidamine, it is shown to induce apoptosis in MDA-MB-231 breast cancer cells. Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number	508578
Brand Family	Calbiochem®
Synonyms	4ʹ-chlorodiazepam, TSPO Activator I, Mitochondrial Translocator Protein Activator I, Ro54864

References
References	Barron, A.M., et al. 2013. The J.Neuroscience. 33, 8891. Yousefi, O.S., et al. 2013. Cell Commun.Signaling. 11, 13. Wu, X., and Gallo, K.E. 2013. PLoS One. 8, e71258. Leonelli, E., et al. 2005. Mech. Ageing. Dev. 126, 1159.

Product Information
CAS number	14439-61-3
Form	Off-white powder
Hill Formula	C₁₆H₁₂Cl₂N₂O
Chemical formula	C₁₆H₁₂Cl₂N₂O
Quality Level	MQ100

Applications

Biological Information
Primary Target	TSPO
Primary Target K<sub>i</sub>	4.4 nM
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
5.08578.0001	04055977262070

Documentation

TSPO Agonist, Ro5-4864 - CAS 14439-61-3 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

参考

参考信息概述
Barron, A.M., et al. 2013. The J.Neuroscience. 33, 8891. Yousefi, O.S., et al. 2013. Cell Commun.Signaling. 11, 13. Wu, X., and Gallo, K.E. 2013. PLoS One. 8, e71258. Leonelli, E., et al. 2005. Mech. Ageing. Dev. 126, 1159.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	18-April-2014 JSW
Synonyms	4ʹ-chlorodiazepam, TSPO Activator I, Mitochondrial Translocator Protein Activator I, Ro54864
Description	A 4′-chloro derivative of diazepam that lacks affinity for GABA-A receptors, but can serve as a ligand for the peripheral benzodiazepine receptor. Acts as an agonist for the 18 kDa translocator protein (TSPO) on the outer mitochondrial membrane (K_d = 4.4 nM). Diminishes the accumulation of β-amyloid peptides in the CA1 hippocampal region of gonadectomized (GDX) mice and in triple transgenic Alzheimer′s disease murine models (3xTgAD). However, it does not affect tau phosphorylation events as assessed by AT8 immunoreactivity. Also shown to reduce GFAP ionized calcium binding adaptor molecule-1 (IBA-1) in the 3xTgAD mice. Reported to increase testosterone and progesterone levels in GDX mice without affecting other steroid hormones. However, it does not have a significant effect on the levels of these hormones in aged 3xTgAD mice. In combination with another mitochondria targeting molecule, lonidamine, it is shown to induce apoptosis in MDA-MB-231 breast cancer cells.
Form	Off-white powder
Intert gas (Yes/No)	Packaged under inert gas
CAS number	14439-61-3
Chemical formula	C₁₆H₁₂Cl₂N₂O
Purity	≥98% by HPLC
Solubility	DMSO (100 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Barron, A.M., et al. 2013. The J.Neuroscience. 33, 8891. Yousefi, O.S., et al. 2013. Cell Commun.Signaling. 11, 13. Wu, X., and Gallo, K.E. 2013. PLoS One. 8, e71258. Leonelli, E., et al. 2005. Mech. Ageing. Dev. 126, 1159.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Activators > Other Activators/Agonists

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