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			96-Well Plate

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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

616394 MilliporeTPEN - CAS 16858-02-9 - Calbiochem

TPEN - CAS 16858-02-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: N,N,Nʹ,Nʹ-tetrakis-(2-Pyridylmethyl)ethylenediamine

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
16858-02-9	C₂₆H₂₈N₆

价格及供货情况

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Description
Overview	Lipid-soluble heavy metal chelator that crosses artificial and natural membranes. Auxiliary reagent in certain techniques used for measuring free Ca²⁺ levels in cells. Also useful in extracting Aβ amyloid deposits from Alzheimer’s disease brain tissue. Has extremely high affinity for heavy metals but low affinity for Ca²⁺ and Mg²⁺. Induces DNA fragmentation when chelated with Zn²⁺ and induces apoptosis in thymocytes. Strips heavy metals from liposome-trapped QUIN 2 (Cat. No. 551826).
Catalogue Number	616394
Brand Family	Calbiochem®
Synonyms	N,N,Nʹ,Nʹ-tetrakis-(2-Pyridylmethyl)ethylenediamine

References
References	Fonte, J., et al. 2001. J. Alzheimer’s Dis. 3, 209. Cherny, R.A., et al. 1999. J. Biol. Chem. 274, 23223. Aballay, A., et al. 1995. Biochem. J. 312, 919. Jiang, S., et al. 1995. Lab. Invest. 73, 111. Sheridan, R.E. and Deshpande, S.S. 1995. Toxicon 33, 539. McCabe, M.J., et al. 1993. Lab. Invest. 69, 101. Hinkle, P.M., et al. 1992. J. Biol. Chem. 267, 25553. Baba, A., et al. 1991. Brain Res. 557, 103. Forbes, I.J., et al. 1991. Exp. Cell Res. 195, 224. Csermely, P. and Somogyi, J. 1989. J. Cellular Physiol. 138, 593. Raspe, E., et al. 1989. Eur. J. Pharmacol. 163, 345. Arslan, L.P., et al. 1985. J. Biol. Chem. 260, 2719.

References

Fonte, J., et al. 2001. J. Alzheimer’s Dis. 3, 209.
Cherny, R.A., et al. 1999. J. Biol. Chem. 274, 23223.
Aballay, A., et al. 1995. Biochem. J. 312, 919.
Jiang, S., et al. 1995. Lab. Invest. 73, 111.
Sheridan, R.E. and Deshpande, S.S. 1995. Toxicon 33, 539.
McCabe, M.J., et al. 1993. Lab. Invest. 69, 101.
Hinkle, P.M., et al. 1992. J. Biol. Chem. 267, 25553.
Baba, A., et al. 1991. Brain Res. 557, 103.
Forbes, I.J., et al. 1991. Exp. Cell Res. 195, 224.
Csermely, P. and Somogyi, J. 1989. J. Cellular Physiol. 138, 593.
Raspe, E., et al. 1989. Eur. J. Pharmacol. 163, 345.
Arslan, L.P., et al. 1985. J. Biol. Chem. 260, 2719.

Product Information
CAS number	16858-02-9
Form	Tan solid
Hill Formula	C₂₆H₂₈N₆
Chemical formula	C₂₆H₂₈N₆
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	≥97% by titration

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+15°C to +30°C
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C) under an inert gas. Alternately, acidify (pH ≤3) with HCl for long term storage. Stock solutions are stable for up to 3 months at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
616394-100MGCN	04055977185621

Documentation

TPEN - CAS 16858-02-9 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

TPEN - CAS 16858-02-9 - Calbiochem 分析证书

标题	批号
616394	输入批号

参考

参考信息概述
Fonte, J., et al. 2001. J. Alzheimer’s Dis. 3, 209. Cherny, R.A., et al. 1999. J. Biol. Chem. 274, 23223. Aballay, A., et al. 1995. Biochem. J. 312, 919. Jiang, S., et al. 1995. Lab. Invest. 73, 111. Sheridan, R.E. and Deshpande, S.S. 1995. Toxicon 33, 539. McCabe, M.J., et al. 1993. Lab. Invest. 69, 101. Hinkle, P.M., et al. 1992. J. Biol. Chem. 267, 25553. Baba, A., et al. 1991. Brain Res. 557, 103. Forbes, I.J., et al. 1991. Exp. Cell Res. 195, 224. Csermely, P. and Somogyi, J. 1989. J. Cellular Physiol. 138, 593. Raspe, E., et al. 1989. Eur. J. Pharmacol. 163, 345. Arslan, L.P., et al. 1985. J. Biol. Chem. 260, 2719.

参考信息概述

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	19-April-2010 RFH
Synonyms	N,N,Nʹ,Nʹ-tetrakis-(2-Pyridylmethyl)ethylenediamine
Description	Lipid-soluble heavy metal chelator that crosses artificial and natural membranes. Auxiliary reagent in certain techniques used for measuring free Ca²⁺ in cells. Has an extremely high affinity for heavy metals but a low affinity for Ca²⁺ and Mg²⁺. Induces DNA fragmentation when chelated with Zn²⁺ and causes apoptosis in thymocytes. Strips heavy metals from liposome-trapped QUIN 2. Shown to be useful in extracting Aβ depostis from Alzheimer's disease brain tissue.
Form	Tan solid
CAS number	16858-02-9
Chemical formula	C₂₆H₂₈N₆
Structure formula
Purity	≥97% by titration
Solubility	DMSO, Ethanol (10 mg/ml), or PBS (25 µM in 100 mM PBS, pH 7.0)
Storage	+15°C to +30°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C) under an inert gas. Alternately, acidify (pH ≤3) with HCl for long term storage. Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Fonte, J., et al. 2001. J. Alzheimer’s Dis. 3, 209. Cherny, R.A., et al. 1999. J. Biol. Chem. 274, 23223. Aballay, A., et al. 1995. Biochem. J. 312, 919. Jiang, S., et al. 1995. Lab. Invest. 73, 111. Sheridan, R.E. and Deshpande, S.S. 1995. Toxicon 33, 539. McCabe, M.J., et al. 1993. Lab. Invest. 69, 101. Hinkle, P.M., et al. 1992. J. Biol. Chem. 267, 25553. Baba, A., et al. 1991. Brain Res. 557, 103. Forbes, I.J., et al. 1991. Exp. Cell Res. 195, 224. Csermely, P. and Somogyi, J. 1989. J. Cellular Physiol. 138, 593. Raspe, E., et al. 1989. Eur. J. Pharmacol. 163, 345. Arslan, L.P., et al. 1985. J. Biol. Chem. 260, 2719.

种类

Life Science Research > Inhibitors and Biochemicals > Biochemicals > Chelating Agents

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