613450 Sigma-AldrichTOFA - CAS 54857-86-2 - Calbiochem
A cell-permeable furoic acid compound that acts as a potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in the fatty acid biosynthesis.
More>> A cell-permeable furoic acid compound that acts as a potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in the fatty acid biosynthesis. Less<<TOFA - CAS 54857-86-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
同义词: 5-(Tetradecyloxy)-2-furoic acid
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概述
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重要规格表
| CAS # | Empirical Formula |
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| 54857-86-2 | C₁₉H₃₂O₄ |
价格及供货情况
| 产品目录编号 | 库存情况 | 包装 | 数量 / 包装 | 价格 | 数量 | |
|---|---|---|---|---|---|---|
| 613450-5MGCN |
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塑胶安瓿;塑胶针药瓶 | 5 mg |
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| Description | |
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| Overview | A cell-permeable furoic acid compound that acts as a potent, reversible, and competitive inhibitor of acetyl-CoA carboxylase (ACC), a key enzyme involved in the fatty acid biosynthesis. Inhibits cellular fatty acid synthesis in a dose-dependent manner (IC50 = 4 µM in human breast cancer cell line MCF7). TOFA-induced reduction in malonyl-CoA is reported to off-set the effect of C75 (Cat. No. 341325) on food intake in fasted mice and on apoptosis in tumor cells. |
| Catalogue Number | 613450 |
| Brand Family | Calbiochem® |
| Synonyms | 5-(Tetradecyloxy)-2-furoic acid |
| Product Information | |
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| CAS number | 54857-86-2 |
| ATP Competitive | Y |
| Form | Off-white solid |
| Hill Formula | C₁₉H₃₂O₄ |
| Chemical formula | C₁₉H₃₂O₄ |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | Acetyl-CoA carboxylase (ACC) |
| Primary Target IC<sub>50</sub> | 4 µM inhibiting cellular fatty acid synthesis in human breast cancer cell line MCF7 |
| Purity | ≥98% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| 产品目录编号 | GTIN |
| 613450-5MGCN | 04055977263787 |
Documentation
TOFA - CAS 54857-86-2 - Calbiochem MSDS
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TOFA - CAS 54857-86-2 - Calbiochem 分析证书
| 标题 | 批号 |
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| 613450 |
参考
| 参考信息概述 |
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| Landree, L.E., et al. 2004. J. Biol. Chem. 279, 3817. Zhou, W., et al. 2003. Cancer Res. 63, 7330. Hu, Z., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 12624. Pizer, E.S., et al. 2000. Cancer Res. 60, 213. Arbeeny, C.M., et al. 1992. J. Lipid Res. 33, 843. Fukuda, N. and Ontko, J.A. 1984. J. Lipid Res. 25, 831. |