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613810 Sigma-AldrichTNAP Inhibitor - CAS 496014-13-2 - Calbiochem

The TNAP Inhibitor, also referenced under CAS 496014-13-2, controls the biological activity of TNAP. This small molecule/inhibitor is primarily used for Cell Structure applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: 2,5-Dimethoxy-N-(quinolin-3-yl)benzenesulfonamide, Tissue-Nonspecific Alkaline Phosphatase Inhibitor, MLS-0038949

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
496014-13-2	C₁₇H₁₆N₂O₄S

价格及供货情况

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Description
Overview	A cell-permeable quinolinyl-benzenesulfonamide compound that acts as a potent reversible inhibitor against tissue-nonspecific (TN) alkaline phosphatase (AP) activity (IC₅₀ = 190 nM) with CYP2C19 being the only other known target, while exhibiting little or no inhibitory activity in over 250 assays involving other enzymes, including, but not limited to, placental and intestinal APs (IC₅₀ > 100 µM), PHOSPHO1 phosphatase, and NPP1 phosphodiesterase. Kinetic studies indicate that the inhibition is uncompetitive with respect to the phosphate donor substrate and noncompetitive with respect to the acceptor substrate, indicating an allosteric inhibition mechanism. Subcutaneous dosing in rats in vivo is reported to result in plasma inhibitor concentrations in the therapeutic range (C_max = 1.5 µg/ml 1 hr after 4.13 mg/kg by s.c.).
Catalogue Number	613810
Brand Family	Calbiochem®
Synonyms	2,5-Dimethoxy-N-(quinolin-3-yl)benzenesulfonamide, Tissue-Nonspecific Alkaline Phosphatase Inhibitor, MLS-0038949

References
References	Dahl, R., et al. 2009. J. Med. Chem. 52, 6919.

Product Information
CAS number	496014-13-2
Form	White solid
Hill Formula	C₁₇H₁₆N₂O₄S
Chemical formula	C₁₇H₁₆N₂O₄S
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	≥95% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and store at (4°C). Stock solutions are stable for up to 6 months at 4°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
613810-10MGCN	04055977263572

Documentation

TNAP Inhibitor - CAS 496014-13-2 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

TNAP Inhibitor - CAS 496014-13-2 - Calbiochem 分析证书

标题	批号
613810	输入批号

参考

参考信息概述
Dahl, R., et al. 2009. J. Med. Chem. 52, 6919.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	19-April-2011 RFH
Synonyms	2,5-Dimethoxy-N-(quinolin-3-yl)benzenesulfonamide, Tissue-Nonspecific Alkaline Phosphatase Inhibitor, MLS-0038949
Description	A cell-permeable quinolinyl-benzenesulfonamide compound that acts as a potent reversible inhibitor against tissue-nonspecific (TN) alkaline phosphatase (AP) activity (IC₅₀ = 190 nM) with CYP2C19 being the only other known target, while exhibiting little or no inhibitory activity in over 250 assays involving other enzymes, including, but not limited to, placental and intestinal APs (IC₅₀ >100 µM), PHOSPHO1 phosphatase, and NPP1 phosphodiesterase. Kinetic studies indicate that the inhibition is uncompetitive with respect to the phosphate donor substrate and noncompetitive with respect to the acceptor substrate, indicating an allosteric inhibition mechanism. Subcutaneous dosing in rats in vivo is reported to result in plasma inhibitor concentrations in the therapeutic range (C_max = 1.5 µg/ml 1 hr after 4.13 mg/kg by s.c.).
Form	White solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	496014-13-2
Chemical formula	C₁₇H₁₆N₂O₄S
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (50 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and store at (4°C). Stock solutions are stable for up to 6 months at 4°C.
Toxicity	Standard Handling
References	Dahl, R., et al. 2009. J. Med. Chem. 52, 6919.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Phosphatase Inhibitors

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