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580563 Sigma-AldrichTCPOBOP - CAS 76150-91-9 - Calbiochem

The most potent known member of the phenobarbital-like class of cytochrome P450 (CYP)-inducing agents.

TCPOBOP - CAS 76150-91-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: 1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene

Primary Target: Cytochrome P450 (CYP)-inducing agents

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
76150-91-9	C₁₆H₈Cl₄N₂O₂

价格及供货情况

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Description
Overview	The most potent known member of the phenobarbital-like class of cytochrome P450 (CYP)-inducing agents. Acts as a tumor promoter of murine hepatocarcinogenesis; activates orphan nuclear receptors mCAR (mouse Constitutive Androstane Receptor) and hPXR (human Pregnane X Receptor), but has little or no activity on hCAR and mPXR. Also suppresses the multidrug resistance gene expression in the mouse liver.
Catalogue Number	580563
Brand Family	Calbiochem®
Synonyms	1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene

References
References	Ledda-Columbano, G.M., et al. 2000. Am. J. Pathol. 156, 91. Moore, L.B., et al. 2000. J. Biol. Chem. 275, 15122. Tzameli, I., et al. 2000. Mol. Cell. Biol. 20, 2951. Forman, B.M., et al. 1998. Nature 395, 612. Honkakoski, P., et al. 1998. Mol. Pharmacol. 53, 597. Russell, A.L., et al. 1994. Int. J. Cancer 58, 550. Smith, G., et al. 1993. Biochem. J. 289, 807. Dargani, T.A., et al. 1990. Carcinogenesis 11, 1153. Poland, A., et al. 1980. Mol. Pharmacol. 18, 571.

References

Ledda-Columbano, G.M., et al. 2000. Am. J. Pathol. 156, 91.
Moore, L.B., et al. 2000. J. Biol. Chem. 275, 15122.
Tzameli, I., et al. 2000. Mol. Cell. Biol. 20, 2951.
Forman, B.M., et al. 1998. Nature 395, 612.
Honkakoski, P., et al. 1998. Mol. Pharmacol. 53, 597.
Russell, A.L., et al. 1994. Int. J. Cancer 58, 550.
Smith, G., et al. 1993. Biochem. J. 289, 807.
Dargani, T.A., et al. 1990. Carcinogenesis 11, 1153.
Poland, A., et al. 1980. Mol. Pharmacol. 18, 571.

Product Information
CAS number	76150-91-9
ATP Competitive	N
Form	White solid
Hill Formula	C₁₆H₈Cl₄N₂O₂
Chemical formula	C₁₆H₈Cl₄N₂O₂
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Cytochrome P450 (CYP)-inducing agents
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	N

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	UT7145000

Safety Information
R Phrase	R: 40 Limited evidence of a carcinogenic effect.
S Phrase	S: 22-36 Do not breathe dust. Wear suitable protective clothing.

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Carcinogenic / Teratogenic
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
580563-25MGCN	04055977265576

Documentation

TCPOBOP - CAS 76150-91-9 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

TCPOBOP - CAS 76150-91-9 - Calbiochem 分析证书

标题	批号
580563	输入批号

参考

参考信息概述
Ledda-Columbano, G.M., et al. 2000. Am. J. Pathol. 156, 91. Moore, L.B., et al. 2000. J. Biol. Chem. 275, 15122. Tzameli, I., et al. 2000. Mol. Cell. Biol. 20, 2951. Forman, B.M., et al. 1998. Nature 395, 612. Honkakoski, P., et al. 1998. Mol. Pharmacol. 53, 597. Russell, A.L., et al. 1994. Int. J. Cancer 58, 550. Smith, G., et al. 1993. Biochem. J. 289, 807. Dargani, T.A., et al. 1990. Carcinogenesis 11, 1153. Poland, A., et al. 1980. Mol. Pharmacol. 18, 571.

参考信息概述

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	12-September-2008 RFH
Synonyms	1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene
Description	A highly potent inducer of phenobarbital-like class of cytochrome P450 (CYP) enzymes. A tumor promoter that induces hepatocyte proliferation, independent of the presence of cytokines or transcription factors. Activates orphan nuclear receptors mCAR (mouse constitutive androstane receptor) and hPXR (human pregane X receptor), but has little or no effect on hCAR and mPXR. Also suppresses the expression of multi-drug resistance genes mdr2 and mdr3 in mouse liver.
Form	White solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	76150-91-9
RTECS	UT7145000
Chemical formula	C₁₆H₈Cl₄N₂O₂
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (5 mg/ml)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Carcinogenic / Teratogenic
References	Ledda-Columbano, G.M., et al. 2000. Am. J. Pathol. 156, 91. Moore, L.B., et al. 2000. J. Biol. Chem. 275, 15122. Tzameli, I., et al. 2000. Mol. Cell. Biol. 20, 2951. Forman, B.M., et al. 1998. Nature 395, 612. Honkakoski, P., et al. 1998. Mol. Pharmacol. 53, 597. Russell, A.L., et al. 1994. Int. J. Cancer 58, 550. Smith, G., et al. 1993. Biochem. J. 289, 807. Dargani, T.A., et al. 1990. Carcinogenesis 11, 1153. Poland, A., et al. 1980. Mol. Pharmacol. 18, 571.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Activators > Other Activators/Agonists

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