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530959 Sigma-AldrichTAZ Activity Modulator, TM-25659 - CAS 260553-97-7 - Calbiochem

A cell-permeable enhancer of nuclear localization of transcriptional co-activator with PDZ-binding motif (TAZ). Does not affect the total amount of TAZ in pluripotent C3H10T1/2 cells.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
参考
技术信息
Data Sheet

同义词: TM25659, TM 25659

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
260553-97-7	C₃₀H₂₈N₈

价格及供货情况

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Description
Overview	A cell permeable, orally bioavailable imidazol-[4,5-b]pyridine derivative that enhances nuclear localization of transcriptional co-activator with PDZ-binding motif (TAZ) in a dose-dependent manner without affecting the total amount of TAZ in pluripotent C3H10T1/2 cells. Does not affect Ser89 phosphorylation in TAZ, but reduces tyrosine phosphorylation. Reduces PPARg levels in differentiated adipocytes and acts as a suppressor of PPARg-dependent adipocyte differentiation. Also shown to enhance RUNX2-induced osteoblast differentiation of C3H10T1/2 cells and mineralization in a dose-dependent manner. Reduces weight gain in ob/ob mice (50 mg/kg, i.p.) and attenuates bone loss in ovariectomized mice. Displays desirable pharmacokinetic properties with t_1/2 = 9.85 h. Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number	530959
Brand Family	Calbiochem®
Synonyms	TM25659, TM 25659

References
References	Jang, E.J., et al. 2012. Br. J. Pharmacol. 165, 1584.

Product Information
CAS number	260553-97-7
Form	Yellow powder
Hill Formula	C₃₀H₂₈N₈
Chemical formula	C₃₀H₂₈N₈
Reversible	Y
Quality Level	MQ100

Applications

Biological Information
Purity	≥97% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
5.30959.0001	04055977283259

Documentation

TAZ Activity Modulator, TM-25659 - CAS 260553-97-7 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

参考

参考信息概述
Jang, E.J., et al. 2012. Br. J. Pharmacol. 165, 1584.

技术信息

标题
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White Paper: Further considerations of antibody validation and usage.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	15-March-2015 JSW
Synonyms	TM25659, TM 25659
Description	A cell permeable, orally bioavailable imidazol-pyrimidine derivative that enhances nuclear localization of transcriptional co-activator with PDZ-binding motif (TAZ) in a dose-dependent manner without affecting the total amount of TAZ in pluripotent C3H10T1/2 cells. Does not affect Ser89 phosphorylation in TAZ, but reduces tyrosine phosphorylation. Reduces PPARg levels in differentiated adipocytes and acts as a suppressor of PPARg-dependent adipocyte differentiation. Also shown to enhance RUNX2-induced osteoblast differentiation of C3H10T1/2 cells and mineralization in a dose-dependent manner. Reduces weight gain in ob/ob mice (50 mg/kg, i.p.) and attenuates bone loss in ovariectomized mice. Displays desirable pharmacokinetic properties with t1/2 = 9.85 h.
Form	Yellow powder
Intert gas (Yes/No)	Packaged under inert gas
CAS number	260553-97-7
Chemical formula	C₃₀H₂₈N₈
Purity	≥97% by HPLC
Solubility	DMSO (50 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Jang, E.J., et al. 2012. Br. J. Pharmacol. 165, 1584.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Inducers > Cell Differentiation Inducers

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