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575310 Sigma-AldrichT0901317 - CAS 293754-55-9 - Calbiochem

A cell-permeable, nonsterol, benzenesulfonamide compound that acts as a highly selective and potent liver X receptor agonist (EC₅₀ of 20 nM for LXRα).

T0901317 - CAS 293754-55-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: TO-901317, N-(2,2,2-Trifluoroethyl)-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]sulfonamide

Primary Target: Liver X receptor (LXRα)

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
293754-55-9	C₁₇H₁₂NSO₃F₉

价格及供货情况

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Description
Overview	A cell-permeable, nonsterol, benzenesulfonamide compound that acts as a highly selective and potent liver X receptor agonist (EC₅₀ of 20 nM for LXR_α). Reported to induce the expression of genes associated with fatty acid biosynthesis and raise both the levels of serum HDL cholesterol and triglyceride in mice. Also reduces the development of atherosclerosis in LDL receptor-deficient mice and lowers plasma glucose in diabetic rodents.
Catalogue Number	575310
Brand Family	Calbiochem®
Synonyms	TO-901317, N-(2,2,2-Trifluoroethyl)-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]sulfonamide

References
References	Terasaka, N., et al. 2003. FEBS Lett. 536, 6. Cao, G., et al. 2002. J. Biol. Chem. 278, 1131. Field, F.J., et al. 2002. Biochem. J. 368, 855. Fukumoto, H., et al. 2002. J. Biol. Chem. 277, 48508. DeBose-Boyd, R.A., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 1477. Repa, J.J., et al. 2000. Science 289, 1524. Schultz, J.R., et al. 2000. Genes Dev. 14, 2831.

Product Information
CAS number	293754-55-9
ATP Competitive	N
Form	Light beige solid
Hill Formula	C₁₇H₁₂NSO₃F₉
Chemical formula	C₁₇H₁₂NSO₃F₉
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Liver X receptor (LXRα)
Primary Target IC<sub>50</sub>	EC50 = 20 nM for LXRα
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Blue Ice Only
Toxicity	Harmful
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
575310-10MGCN	04055977189254

Documentation

T0901317 - CAS 293754-55-9 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

T0901317 - CAS 293754-55-9 - Calbiochem 分析证书

标题	批号
575310	输入批号

参考

参考信息概述
Terasaka, N., et al. 2003. FEBS Lett. 536, 6. Cao, G., et al. 2002. J. Biol. Chem. 278, 1131. Field, F.J., et al. 2002. Biochem. J. 368, 855. Fukumoto, H., et al. 2002. J. Biol. Chem. 277, 48508. DeBose-Boyd, R.A., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 1477. Repa, J.J., et al. 2000. Science 289, 1524. Schultz, J.R., et al. 2000. Genes Dev. 14, 2831.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	22-May-2014 JSW
Synonyms	TO-901317, N-(2,2,2-Trifluoroethyl)-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]sulfonamide
Description	A cell-permeable, nonsterol, benzenesulfonamide compound that acts as a highly selective and potent liver X receptor agonist (EC₅₀ = 20 nM for LXRα). Reported to induce the expression of genes associated with fatty acid biosynthesis. Raises the levels of serum HDL cholesterol and triglycerides in mice and inhibits the development of atherosclerosis in LDL receptor-deficient mice. Also shown to lower plasma glucose levels in diabetic rodents.
Form	Light beige solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	293754-55-9
Chemical formula	C₁₇H₁₂NSO₃F₉
Structure formula
Purity	≥98% by HPLC
Solubility	DMSO (50 mg/ml) or Ethanol (50 mg/ml)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Harmful
References	Terasaka, N., et al. 2003. FEBS Lett. 536, 6. Cao, G., et al. 2002. J. Biol. Chem. 278, 1131. Field, F.J., et al. 2002. Biochem. J. 368, 855. Fukumoto, H., et al. 2002. J. Biol. Chem. 277, 48508. DeBose-Boyd, R.A., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 1477. Repa, J.J., et al. 2000. Science 289, 1524. Schultz, J.R., et al. 2000. Genes Dev. 14, 2831.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Activators > Other Activators/Agonists

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