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574714 Sigma-AldrichSyk Inhibitor IV, BAY 61-3606 - CAS 732983-37-8 - Calbiochem

Syk Inhibitor IV, BAY 61-3606, CAS 732938-37-8, is a cell-permeable, potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (IC50 = 10 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: 2-(7-(3,4-Dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino)-nicotinamide, HCl, BAY 61-3606

Primary Target: Syk

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
732983-37-8	C₂₀H₁₈N₆O₃ • HCl • H₂O

价格及供货情况

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Description
Overview	A cell-permeable imidazopyrimidine compound that acts a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (IC₅₀ = 10 nM) with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src even at concentrations as high as 4.7 µM. Shown to inhibit Syk-mediated cellular functions in vitro and exhibit good oral bioavailability and in vivo effacacy in the treatment of various allgery and asthma conditions in rat models.
Catalogue Number	574714
Brand Family	Calbiochem®
Synonyms	2-(7-(3,4-Dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino)-nicotinamide, HCl, BAY 61-3606

References
References	Yamamoto, N., et al. 2003. J. Pharm. Exp. Ther. 306, 1174.

Product Information
CAS number	732983-37-8
ATP Competitive	Y
Form	Yellow solid
Hill Formula	C₂₀H₁₈N₆O₃ • HCl • H₂O
Chemical formula	C₂₀H₁₈N₆O₃ • HCl • H₂O
Hygroscopic	Hygroscopic
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications
Application	Syk Inhibitor IV, BAY 61-3606, CAS 732938-37-8, is a cell-permeable, potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (IC50 = 10 nM).

Biological Information
Primary Target	Syk
Primary Target IC<sub>50</sub>	10 nM
Purity	≥97% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
574714-2MGCN	04055977189698

Documentation

Syk Inhibitor IV, BAY 61-3606 - CAS 732983-37-8 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Syk Inhibitor IV, BAY 61-3606 - CAS 732983-37-8 - Calbiochem 分析证书

标题	批号
574714	输入批号

参考

参考信息概述
Yamamoto, N., et al. 2003. J. Pharm. Exp. Ther. 306, 1174.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	03-September-2020 JSW
Synonyms	2-(7-(3,4-Dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino)-nicotinamide, HCl, BAY 61-3606
Description	A cell-permeable imidazopyrimidine compound that acts a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (IC₅₀ = 10 nM) with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src even at concentrations as high as 4.7 µM. Shown to inhibit Syk-mediated cellular functions in vitro and exhibit good oral bioavailability and in vivo effacacy in the treatment of various allgery and asthma conditions in rat models.
Form	Yellow solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	732983-37-8
Chemical formula	C₂₀H₁₈N₆O₃ • HCl • H₂O
Structure formula
Purity	≥97% by HPLC
Solubility	DMSO (10 mg/ml) or H₂O (20 mg/ml)
Storage	Protect from light +2°C to +8°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Yamamoto, N., et al. 2003. J. Pharm. Exp. Ther. 306, 1174.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Tyrosine Kinase (PTK) Inhibitors

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