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574713 Sigma-AldrichSyk Inhibitor III - CAS 1485-00-3 - Calbiochem

The Syk Inhibitor III, also referenced under CAS 1485-00-3, controls the biological activity of Syk. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: 3,4-Methylenedioxy-β-nitrostyrene

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概述

Replacement Information

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Description
Overview	A cell-permeable nitrostyrene compound that acts as a selective inhibitor of Syk kinase activity (IC₅₀ = 2.5 µM). It inhibits Src only at much higher concentrations (IC₅₀ = 29.3 µM) and exhibits little effect against Fak and JAK2. Shown to potently inhibit platelet aggregation induced by various stimulators, including U46619, ADP, arachidonic acid, collagen, thrombin, ionophore A23187, and PDBu (IC₅₀ ranges from 2.1 to 25.9 µM).
Catalogue Number	574713
Brand Family	Calbiochem®
Synonyms	3,4-Methylenedioxy-β-nitrostyrene

References
References	Wang, W.Y., et al. 2006. Mol. Pharmacol. 70, 1380.

Product Information
CAS number	1485-00-3
ATP Competitive	N
Form	Yellow to brown solid
Hill Formula	C₉H₇NO₄
Chemical formula	C₉H₇NO₄
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Syk
Primary Target IC<sub>50</sub>	2.5 µM against Syk kinase activity
Purity	≥98% by GC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	WL5270000

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Irritant
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
574713-50MGCN	04055977189681

Documentation

Syk Inhibitor III - CAS 1485-00-3 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Syk Inhibitor III - CAS 1485-00-3 - Calbiochem 分析证书

标题	批号
574713	输入批号

参考

参考信息概述
Wang, W.Y., et al. 2006. Mol. Pharmacol. 70, 1380.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	29-April-2016 JSW
Synonyms	3,4-Methylenedioxy-β-nitrostyrene
Description	A cell-permeable nitrostyrene compound that acts as a selective inhibitor of Syk kinase activity (IC₅₀ = 2.5 µM). It inhibits Src only at much higher concentrations (IC₅₀ = 29.3 µM) and exhibits little effect against Fak and JAK2. Shown to potently inhibit platelet aggregation induced by various stimulators, including U46619, ADP, arachidonic acid, collagen, thrombin, ionophore A23187, and PDBu (IC₅₀ ranges from 2.1 to 25.9 µM).
Form	Yellow to brown solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	1485-00-3
RTECS	WL5270000
Chemical formula	C₉H₇NO₄
Structure formula
Purity	≥98% by GC
Solubility	DMSO (25 mg/ml). Use only fresh DMSO.
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Irritant
References	Wang, W.Y., et al. 2006. Mol. Pharmacol. 70, 1380.

种类

Life Science Research > Inhibitors and Biochemicals

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