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A cell-permeable hydroxyindolinone compound that acts as a selective antagonist of survivin. Induces mitotic arrest and blocks cell cycle at G2/M phase (~40 µM in HeLA cells) leading to apoptotic cell death. Shown to bind to a specific cavity adjacent to the interface involved in the dimerization of survivin. Binding is specific only to native survivin and does not affect any mutant forms. Inhibits HCT116 cell proliferation independently of their p53 status and reduces tumor volume in xenograft models in a dose-dependent manner (5 to 15 mg/kg).
Catalogue Number
574661
Brand Family
Calbiochem®
Synonyms
3-(2-(benzo[d][1,3]dioxol-5-yl)-2-oxoethyl)-5-bromo-3-hydroxyindolin-2-one, Survivin Inhibitor II
Survivin Antagonist, S12 - CAS 258264-62-9 - Calbiochem 分析证书
标题
批号
574661
参考
参考信息概述
Berezov, A., et al. 2011. Oncogene31, 1938.
数据表
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
08-June-2012 JSW
Synonyms
3-(2-(benzo[d][1,3]dioxol-5-yl)-2-oxoethyl)-5-bromo-3-hydroxyindolin-2-one, Survivin Inhibitor II
Description
A cell-permeable hydroxyindolinone compound that acts as a selective antagonist of survivin. Induces mitotic arrest and blocks cell cycle at G2/M phase (~40 µM in HeLA cells) leading to apoptotic cell death. Shown to bind to a specific cavity adjacent to the interface involved in the dimerization of survivin. Binding is specific only to native survivin and does not affect any mutant forms. Inhibits HCT116 cell proliferation independently of their p53 status and reduces tumor volume in xenograft models in a dose-dependent manner (5 to 15 mg/kg).
Form
White solid
Intert gas (Yes/No)
Packaged under inert gas
CAS number
258264-62-9
Chemical formula
C₁₇H₁₂BrNO₅
Structure formula
Purity
≥98% by HPLC
Solubility
DMSO (50 mg/ml; nearly colorless solution)
Storage
Protect from light
-20°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
