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			96-Well Plate

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574625 Sigma-AldrichSuramin, Sodium Salt - CAS 129-46-4 - Calbiochem

A reversible and competitive inhibitor of protein tyrosine phosphatases.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
数据表
Data Sheet

同义词: Purinergic Receptor P2Y Antagonist I, PTP Inhibitor VI, P2Y Antagonist I

Primary Target: protein tyrosine phosphatases

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
129-46-4	C₅₁H₃₄N₆O₂₃S₆ . 6Na

价格及供货情况

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Description
Overview	A reversible and competitive inhibitor of protein tyrosine phosphatases. An anti-neoplastic, anti-angiogenic agent that uncouples G-proteins from receptors presumably by blocking their interaction with intracellular receptor domains. Inhibits GDP-GTP exchange, the rate limiting step in the activation of G_α-subunits. A competitive inhibitor of reverse transcriptase. Reported to inhibit topoisomerases I and II. Inhibits Ca²⁺-ATPase in sarcoplasmic reticulum membranes. Also inhibits the cell-surface binding of various growth factors, including EGF, PDGF, and TGF-β. An inhibitor of phospholipase D (IC₅₀ = 15 µM). Reported to interact with ATP-binding enzymes and P₂-purinergic receptors. An effective inhibitor of angiogenesis in the calmodulin assay when given in combination with angiostatic steroids.
Catalogue Number	574625
Brand Family	Calbiochem®
Synonyms	Purinergic Receptor P2Y Antagonist I, PTP Inhibitor VI, P2Y Antagonist I

References
References	Meyers, M.O., et al. 2000. J. Surg. Res. 91, 130. Hohenegger, M., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 346. Waldhoer, M., et al. 1998. Mol. Pharmacol. 53, 808. Zhang, Y.L., et al. 1998. J. Biol. Chem. 273, 12281. Hohenegger, M., et al. 1996. Mol. Pharmacol. 50, 1443. Emmick, J.J., et al. 1994. J. Pharmacol. Exp. Ther. 269, 717. Denhertog, A., et al. 1992. J. Physiol. 454, 591. Nakajima, M., et al. 1991. J. Biol. Chem. 266, 9661. Wilks, J.W., et al. 1991. Int. J. Radiat. Biol. 60, 73. Huang, R.C., et al. 1990. Mol. Pharmacol. 37, 304. Kopp, R. and Pfeiffer, A. 1990. Cancer Res. 50, 6490.

References

Meyers, M.O., et al. 2000. J. Surg. Res. 91, 130.
Hohenegger, M., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 346.
Waldhoer, M., et al. 1998. Mol. Pharmacol. 53, 808.
Zhang, Y.L., et al. 1998. J. Biol. Chem. 273, 12281.
Hohenegger, M., et al. 1996. Mol. Pharmacol. 50, 1443.
Emmick, J.J., et al. 1994. J. Pharmacol. Exp. Ther. 269, 717.
Denhertog, A., et al. 1992. J. Physiol. 454, 591.
Nakajima, M., et al. 1991. J. Biol. Chem. 266, 9661.
Wilks, J.W., et al. 1991. Int. J. Radiat. Biol. 60, 73.
Huang, R.C., et al. 1990. Mol. Pharmacol. 37, 304.
Kopp, R. and Pfeiffer, A. 1990. Cancer Res. 50, 6490.

Product Information
CAS number	129-46-4
ATP Competitive	N
Form	White to beige to peach crystalline solid
Hill Formula	C₅₁H₃₄N₆O₂₃S₆ . 6Na
Chemical formula	C₅₁H₃₄N₆O₂₃S₆ . 6Na
Hygroscopic	Hygroscopic
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	protein tyrosine phosphatases
Primary Target IC<sub>50</sub>	15 µM against phospholipase D
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	N

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	QM7000000

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
574625-50MGCN	04055977189636

Documentation

Suramin, Sodium Salt - CAS 129-46-4 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Suramin, Sodium Salt - CAS 129-46-4 - Calbiochem 分析证书

标题	批号
574625	输入批号

参考

参考信息概述
Meyers, M.O., et al. 2000. J. Surg. Res. 91, 130. Hohenegger, M., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 346. Waldhoer, M., et al. 1998. Mol. Pharmacol. 53, 808. Zhang, Y.L., et al. 1998. J. Biol. Chem. 273, 12281. Hohenegger, M., et al. 1996. Mol. Pharmacol. 50, 1443. Emmick, J.J., et al. 1994. J. Pharmacol. Exp. Ther. 269, 717. Denhertog, A., et al. 1992. J. Physiol. 454, 591. Nakajima, M., et al. 1991. J. Biol. Chem. 266, 9661. Wilks, J.W., et al. 1991. Int. J. Radiat. Biol. 60, 73. Huang, R.C., et al. 1990. Mol. Pharmacol. 37, 304. Kopp, R. and Pfeiffer, A. 1990. Cancer Res. 50, 6490.

参考信息概述

数据表

标题
SIRTainty™ Class III HDAC Assay

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	13-October-2020 JSW
Synonyms	Purinergic Receptor P2Y Antagonist I, PTP Inhibitor VI, P2Y Antagonist I
Description	An anti-neoplastic, anti-angiogenic agent that uncouples G-proteins from receptors presumably by blocking their interaction with intracellular receptor domains. A competitive inhibitor of reverse transcriptase. Reported to inhibit topoisomerase I and II. Inhibits Ca²⁺-ATPase in sarcoplasmic reticulum membranes. Also inhibits the cell-surface binding of various growth factors including EGF, PDGF, and TGF-β. An inhibitor of phospholipase D (IC₅₀ = 15 µM). Reported to interact with ATP-binding enzymes and P₂-purinergic receptors. An effective inhibitor of angiogenesis in calmodulin assays when given in combination with angiostatic steroids.
Form	White to beige to peach crystalline solid
CAS number	129-46-4
RTECS	QM7000000
Chemical formula	C₅₁H₃₄N₆O₂₃S₆ . 6Na
Structure formula
Purity	≥98% by HPLC
Solubility	H₂O (5 mg/ml)
Storage	+2°C to +8°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity	Standard Handling
Merck USA index	14, 9006
References	Meyers, M.O., et al. 2000. J. Surg. Res. 91, 130. Hohenegger, M., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 346. Waldhoer, M., et al. 1998. Mol. Pharmacol. 53, 808. Zhang, Y.L., et al. 1998. J. Biol. Chem. 273, 12281. Hohenegger, M., et al. 1996. Mol. Pharmacol. 50, 1443. Emmick, J.J., et al. 1994. J. Pharmacol. Exp. Ther. 269, 717. Denhertog, A., et al. 1992. J. Physiol. 454, 591. Nakajima, M., et al. 1991. J. Biol. Chem. 266, 9661. Wilks, J.W., et al. 1991. Int. J. Radiat. Biol. 60, 73. Huang, R.C., et al. 1990. Mol. Pharmacol. 37, 304. Kopp, R. and Pfeiffer, A. 1990. Cancer Res. 50, 6490.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > ATPase/GTPase Inhibitors > ATPase Inhibitors

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Cell Cycle/Cell Division > Topoisomerase Related Inhibitors

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Phosphatase Inhibitors

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