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			96-Well Plate

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574102 Sigma-AldrichSulindac Sulfide - CAS 32004-67-4 - Calbiochem

A cell-permeable, active metabolite of Sulindac.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: (Z)-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic Acid

Primary Target: COX-1

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
32004-67-4	C₂₀H₁₇FO₂S

价格及供货情况

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Description
Overview	A cell-permeable, active metabolite of Sulindac (Cat. No. 574100). Strongly inhibits Ras-induced malignant transformation and Ras/Raf-dependent transactivation. Also decreases the Ras-induced activation of c-Raf-1 kinase. Inhibits growth and induces apoptosis in prostate cancer cell lines. Selectively inhibits COX-1 (ID₅₀ = 500 nM) compared to prostaglandin H synthase-2 (PGHS-2; COX-2; ID₅₀ = 14 µM). Preferentially inhibits the secretion of Aβ₄₂ in CHO cells stably transfected with both APP₇₅, and the PS1 mutant M146L.
Catalogue Number	574102
Brand Family	Calbiochem®
Synonyms	(Z)-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic Acid

References
References	Weggen, S., et al. 2001. Nature 414, 212. Lim, J.T., et al. 1999. Biochem. Pharmacol. 58, 1097. Herrmann, C., et al. 1998. Oncogene 17, 1769. Picariello, L., et al. 1998. Eur. J. Pharmacol. 360, 105. Arber, N., et al. 1997. Gastroenterology 113, 1892. Meade, E.A., et al. 1993. J. Biol. Chem. 268, 6610.

Product Information
CAS number	32004-67-4
ATP Competitive	N
Form	Yellow-orange solid
Hill Formula	C₂₀H₁₇FO₂S
Chemical formula	C₂₀H₁₇FO₂S
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	COX-1
Primary Target IC<sub>50</sub>	ID50 = 500 nM against COX-1
Purity	≥98% by TLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information
R Phrase	R: 22-42/43-63 Harmful if swallowed. May cause sensitization by inhalation and skin contact. Possible risk of harm to the unborn child.
S Phrase	S: 36 Wear suitable protective clothing.

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Harmful & Carcinogenic / Teratogenic
Storage	+15°C to +30°C
Do not freeze	Ok to freeze

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
574102-5MGCN	04055977189551

Documentation

Sulindac Sulfide - CAS 32004-67-4 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Sulindac Sulfide - CAS 32004-67-4 - Calbiochem 分析证书

标题	批号
574102	输入批号

参考

参考信息概述
Weggen, S., et al. 2001. Nature 414, 212. Lim, J.T., et al. 1999. Biochem. Pharmacol. 58, 1097. Herrmann, C., et al. 1998. Oncogene 17, 1769. Picariello, L., et al. 1998. Eur. J. Pharmacol. 360, 105. Arber, N., et al. 1997. Gastroenterology 113, 1892. Meade, E.A., et al. 1993. J. Biol. Chem. 268, 6610.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	12-September-2008 RFH
Synonyms	(Z)-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic Acid
Description	An active metabolite of the non-steroidal anti-inflammatory drug Sulindac (Cat. No. 574100). Inhibits Ras signaling. Strongly inhibits Ras-induced malignant transformation and Ras/Raf-dependent transactivation. Also decreases the Ras-induced activation of c-Raf-1 kinase. Inhibits cell growth and induces apoptosis in a time-and dose-dependent manner. Selectively inhibits prostaglandin H synthase-1 (PGHS-1; COX-1; ID₅₀ = 0.5 µM) relative to prostaglandin H synthase-2 (PGHS-2; COX-2; ID₅₀ = 14 µM). Reduces Aβ₄₂ production independently of COX inhibition.
Form	Yellow-orange solid
CAS number	32004-67-4
Chemical formula	C₂₀H₁₇FO₂S
Structure formula
Purity	≥98% by TLC
Solubility	DMSO (25 mg/ml) or ethanol (5 mg/ml)
Storage	+15°C to +30°C
Do Not Freeze	Ok to freeze
Toxicity	Harmful & Carcinogenic / Teratogenic
References	Weggen, S., et al. 2001. Nature 414, 212. Lim, J.T., et al. 1999. Biochem. Pharmacol. 58, 1097. Herrmann, C., et al. 1998. Oncogene 17, 1769. Picariello, L., et al. 1998. Eur. J. Pharmacol. 360, 105. Arber, N., et al. 1997. Gastroenterology 113, 1892. Meade, E.A., et al. 1993. J. Biol. Chem. 268, 6610.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Lipid Signaling Inhibitors > Cyclooxygenase (COX) Inhibitors

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