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			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

5677 Sigma-AldrichSpermine, Tetrahydrochloride - CAS 306-67-2 - Calbiochem

Polyamine that plays an important role in the regulation of cellular proliferation and differentiation.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
Data Sheet

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
306-67-2	C₁₀H₂₆N₄ . 4HCl

价格及供货情况

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Description
Overview	Polyamine that plays an important role in the regulation of cellular proliferation and differentiation. Has both stimulatory and inhibitory effects on NMDA receptors depending on the subunit composition of the receptor. Acts as an inhibitor of phospholipase Cα and an activator of phospholipase Cδ. Inhibits DNA fragmentation and morphological apoptosis. Inhibits neuronal NOS.
Catalogue Number	5677
Brand Family	Calbiochem®

References
References	Igarashi, K. and Williams, K. 1995. J. Pharmacol. Exp. Ther. 272, 1101. Escargueil-Blanc, I., et al. 1994. FASEB J. 8, 1075. Hu, J., et al. 1994. Neurosci. Lett. 175, 41. Tompkins, T.A. and Moscarello, M.A. 1994. Biochim. Biophys. Acta 1206, 1208. Trubiani, O., et al. 1994. Biochem. Mol. Biol. Int. 32, 1085. Svensson, F., et al. 1993. Mol. Cell. Biochem. 124, 141. Ask, A., et al. 1992. Cancer Lett. 66, 29. Chida, N., et al. 1992. Brain Res. 593, 57. Khan, A.U., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 11428. Messena, L., et al. 1992. J. Leukoc. Biol. 52, 585. Pawelczyk, T., et al. 1992. Arch. Biochem. Biophys. 297, 328. Shantz, L.M., et al. 1992. Biochem. J. 288, 511.

References

Igarashi, K. and Williams, K. 1995. J. Pharmacol. Exp. Ther. 272, 1101.
Escargueil-Blanc, I., et al. 1994. FASEB J. 8, 1075.
Hu, J., et al. 1994. Neurosci. Lett. 175, 41.
Tompkins, T.A. and Moscarello, M.A. 1994. Biochim. Biophys. Acta 1206, 1208.
Trubiani, O., et al. 1994. Biochem. Mol. Biol. Int. 32, 1085.
Svensson, F., et al. 1993. Mol. Cell. Biochem. 124, 141.
Ask, A., et al. 1992. Cancer Lett. 66, 29.
Chida, N., et al. 1992. Brain Res. 593, 57.
Khan, A.U., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 11428.
Messena, L., et al. 1992. J. Leukoc. Biol. 52, 585.
Pawelczyk, T., et al. 1992. Arch. Biochem. Biophys. 297, 328.
Shantz, L.M., et al. 1992. Biochem. J. 288, 511.

Product Information
CAS number	306-67-2
Form	White solid
Hill Formula	C₁₀H₂₆N₄ . 4HCl
Chemical formula	C₁₀H₂₆N₄ . 4HCl
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	phospholipase C α
Secondary target	nNOS
Purity	≥99% by titration

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	EJ7230000

Safety Information
R Phrase	R: 36/37/38 Irritating to eyes, respiratory system and skin.
S Phrase	S: 26-36 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing.

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Irritant
Storage	+15°C to +30°C
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot, purge with inert gas, and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C under inert gas.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
5677-5GMCN	04055977190939

Documentation

Spermine, Tetrahydrochloride - CAS 306-67-2 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Spermine, Tetrahydrochloride - CAS 306-67-2 - Calbiochem 分析证书

标题	批号
5677	输入批号

参考

参考信息概述
Igarashi, K. and Williams, K. 1995. J. Pharmacol. Exp. Ther. 272, 1101. Escargueil-Blanc, I., et al. 1994. FASEB J. 8, 1075. Hu, J., et al. 1994. Neurosci. Lett. 175, 41. Tompkins, T.A. and Moscarello, M.A. 1994. Biochim. Biophys. Acta 1206, 1208. Trubiani, O., et al. 1994. Biochem. Mol. Biol. Int. 32, 1085. Svensson, F., et al. 1993. Mol. Cell. Biochem. 124, 141. Ask, A., et al. 1992. Cancer Lett. 66, 29. Chida, N., et al. 1992. Brain Res. 593, 57. Khan, A.U., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 11428. Messena, L., et al. 1992. J. Leukoc. Biol. 52, 585. Pawelczyk, T., et al. 1992. Arch. Biochem. Biophys. 297, 328. Shantz, L.M., et al. 1992. Biochem. J. 288, 511.

参考信息概述

小册子

标题
Caspases and other Apoptosis Related Tools Brochure
Excitotoxic Glutamate Analogs Technical Bulletin

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	08-October-2007 JSW
Description	Polyamine that plays an important role in the regulation of cellular proliferation and differentiation. Acts as an inhibitor of phopholipase C-α and an activator of phopholipase C-δ. Has both stimulatory and inhibitory effects on NMDA receptors depending on the subunit composition of the receptor. Inhibits neuronal NOS. Inhibits DNA fragmentation and morphological apoptosis.
Form	White solid
CAS number	306-67-2
RTECS	EJ7230000
Chemical formula	C₁₀H₂₆N₄ . 4HCl
Structure formula
Purity	≥99% by titration
Solubility	H₂O (20 mg/ml)
Storage	+15°C to +30°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot, purge with inert gas, and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C under inert gas.
Toxicity	Irritant
Merck USA index	14, 8743
References	Igarashi, K. and Williams, K. 1995. J. Pharmacol. Exp. Ther. 272, 1101. Escargueil-Blanc, I., et al. 1994. FASEB J. 8, 1075. Hu, J., et al. 1994. Neurosci. Lett. 175, 41. Tompkins, T.A. and Moscarello, M.A. 1994. Biochim. Biophys. Acta 1206, 1208. Trubiani, O., et al. 1994. Biochem. Mol. Biol. Int. 32, 1085. Svensson, F., et al. 1993. Mol. Cell. Biochem. 124, 141. Ask, A., et al. 1992. Cancer Lett. 66, 29. Chida, N., et al. 1992. Brain Res. 593, 57. Khan, A.U., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 11428. Messena, L., et al. 1992. J. Leukoc. Biol. 52, 585. Pawelczyk, T., et al. 1992. Arch. Biochem. Biophys. 297, 328. Shantz, L.M., et al. 1992. Biochem. J. 288, 511.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Lipid Signaling Inhibitors > Phospholipase Inhibitors

Life Science Research > Inhibitors and Biochemicals > Biochemicals > Life Science Relevant Organics and Inorganics > Salts, Acids and Bases

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