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			96-Well Plate

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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

567375 Sigma-AldrichSmac-N7 Peptide, Cell-Permeable - Calbiochem

The Smac-N7 peptide is modified to be cell permeant by linking the lysine carboxyl terminal to the arginine of Antennapedia homeodomain 16-mer peptide via a proline linker.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
Data Sheet

同义词: AVPIAQKPRQIKIWFQNRRMKWKK

Primary Target: Promotes procaspase-3 activation

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概述

Replacement Information

重要规格表

Empirical Formula
C₁₄₂H₂₃₂N₄₄O₂₉S

价格及供货情况

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Description
Overview	The Smac-N7 peptide (Cat. No. 567370) is modified to be cell permeant by linking the lysine carboxyl terminal to the arginine of Antennapedia homeodomain 16-mer peptide via a proline linker.
Catalogue Number	567375
Brand Family	Calbiochem®
Synonyms	AVPIAQKPRQIKIWFQNRRMKWKK

References
References	Srinivasula, S.M., et al. 2001. Nature 410, 112. Chai, J., et al. 2000. Nature 406, 855. Liu, Z., et al. 2000. Nature 408, 1004. Srinivasula, S.M., et al. 2000. J. Biol. Chem. 275, 36152.

Product Information
ATP Competitive	N
Form	Lyophilized
Formulation	Supplied as a trifluoroacetate salt.
Hill Formula	C₁₄₂H₂₃₂N₄₄O₂₉S
Chemical formula	C₁₄₂H₂₃₂N₄₄O₂₉S
Reversible	N
Quality Level	MQ100

Applications

Biological Information
Primary Target	Promotes procaspase-3 activation
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y
Peptide Sequence	H-Ala-Val-Pro-Ile-Ala-Gln-Lys-Pro-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-OH

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
567375-1MGCN	07790788051594

Documentation

Smac-N7 Peptide, Cell-Permeable - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Smac-N7 Peptide, Cell-Permeable - Calbiochem 分析证书

标题	批号
567375	输入批号

参考

参考信息概述
Srinivasula, S.M., et al. 2001. Nature 410, 112. Chai, J., et al. 2000. Nature 406, 855. Liu, Z., et al. 2000. Nature 408, 1004. Srinivasula, S.M., et al. 2000. J. Biol. Chem. 275, 36152.

小册子

标题
Caspases and other Apoptosis Related Tools Brochure

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	11-September-2008 RFH
Synonyms	AVPIAQKPRQIKIWFQNRRMKWKK
Description	The Smac-N7 peptide (Cat. No. 567370) where the lysine carboxy terminal is linked to the arginine of Antennapedia homeodomain 16-mer peptide (underlined) via a proline linker to make it cell-permeable. Smac-N7 peptide contains the N-terminal seven residues of Smac and promotes the activation of procaspase-3 (~10 µM). Also, promotes the catalytic activity of caspase-9 in the presence of XIAP.
Form	Lyophilized
Formulation	Supplied as a trifluoroacetate salt.
Intert gas (Yes/No)	Packaged under inert gas
Chemical formula	C₁₄₂H₂₃₂N₄₄O₂₉S
Peptide Sequence	H-Ala-Val-Pro-Ile-Ala-Gln-Lys-Pro-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-OH
Purity	≥95% by HPLC
Solubility	DMSO (5 mg/ml)
Storage	-20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Standard Handling
References	Srinivasula, S.M., et al. 2001. Nature 410, 112. Chai, J., et al. 2000. Nature 406, 855. Liu, Z., et al. 2000. Nature 408, 1004. Srinivasula, S.M., et al. 2000. J. Biol. Chem. 275, 36152.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Inducers > Apoptosis Inducers

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