数量	产品目录编号	订购说明	数量 / 包装	公开价
			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

567021 Sigma-AldrichSimvastatin, Sodium Salt - Calbiochem

Simvastatin, Sodium Salt is a carboxylate form of Simvastatin. Active in whole cells and in cell-free preparations. An inhibitor of HMG-CoA reductase.

Simvastatin, Sodium Salt - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

分析证书
参考
Data Sheet

同义词: L-Type Calcium Channel Blocker VI

Primary Target: 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase

Recommended Products

概述

Replacement Information

重要规格表

Empirical Formula
C₂₅H₃₉O₆ • Na

价格及供货情况

产品目录编号	库存情况	包装	数量 / 包装	价格	数量
567021-50MGCN	正在查询供货情况...... — 目前缺货有货停产少量现货供货情况有待确认登录查看库存有货目前缺货有货其余：另行通知其余：另行通知另行通知联系客户服务 Contact Customer Service 联系客户服务联系客户服务	玻璃瓶	50 mg	正在检索价格...... 无法检索价格。最小订购数量为倍数 Maximum Quantity is 以订单确认为准更多信息您节约了 ()。 — Request Pricing 登录查看价格	查看库存情况 —	添加到收藏夹添加到收藏夹添加到我的收藏夹
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Description
Overview	Carboxylate form of Simvastatin (Cat. No. 567020) that is active in whole cells and in cell-free preparations. Also available as a 10 mM solution in H₂O (Cat. No. 567022).
Catalogue Number	567021
Brand Family	Calbiochem®
Synonyms	L-Type Calcium Channel Blocker VI

References
References	Yada, T., et al. 1999. Br. J. Pharmacol. 126, 1205. Clutterbuck, R.D., et al. 1998. Br. J. Haematol. 102, 522. Yokoyama, K., et al. 1998. Mol. Biochem. Parasitol. 94, 87. Negre-Aminou, P., et al. 1997. Biochim. Biophys. Acta 1345, 259. Vrtovsnik, F., et al. 1997. Kidney Int. 52, 1016. Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602.

Product Information
ATP Competitive	N
Form	Beige solid
Hill Formula	C₂₅H₃₉O₆ • Na
Chemical formula	C₂₅H₃₉O₆ • Na
Hygroscopic	Hygroscopic
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase
Purity	≥97% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
567021-50MGCN	04055977267112
567021-5MGCN	07790788051587

Documentation

Simvastatin, Sodium Salt - Calbiochem 分析证书

标题	批号
567021	输入批号

参考

参考信息概述
Yada, T., et al. 1999. Br. J. Pharmacol. 126, 1205. Clutterbuck, R.D., et al. 1998. Br. J. Haematol. 102, 522. Yokoyama, K., et al. 1998. Mol. Biochem. Parasitol. 94, 87. Negre-Aminou, P., et al. 1997. Biochim. Biophys. Acta 1345, 259. Vrtovsnik, F., et al. 1997. Kidney Int. 52, 1016. Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	13-October-2015 JSW
Synonyms	L-Type Calcium Channel Blocker VI
Description	Carboxylate form of Simvastatin (Cat. No. 567020) that is active in whole cells and in cell-free assays. A lipophilic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks Ras function through inhibition of farnesylation. Also inhibits glucose-induced Ca²⁺-signaling and insulin secretion by blocking L-type Ca²⁺ channels in rat islet β-cells. Inhibits cell proliferation of human smooth muscle cells. Note: This product is supplied in an active form; no treatment with NaOH in ethanol is required for its activation.
Form	Beige solid
Intert gas (Yes/No)	Packaged under inert gas
Chemical formula	C₂₅H₃₉O₆ • Na
Structure formula
Purity	≥97% by HPLC
Solubility	DMSO (100 mg/ml), Ethanol (25 mg/ml), or H₂O (5 mg/ml)
Storage	-20°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity	Standard Handling
References	Yada, T., et al. 1999. Br. J. Pharmacol. 126, 1205. Clutterbuck, R.D., et al. 1998. Br. J. Haematol. 102, 522. Yokoyama, K., et al. 1998. Mol. Biochem. Parasitol. 94, 87. Negre-Aminou, P., et al. 1997. Biochim. Biophys. Acta 1345, 259. Vrtovsnik, F., et al. 1997. Kidney Int. 52, 1016. Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Lipid Signaling Inhibitors > HMG-CoA (3-Hydroxy-3-Methylglutaryl Coenzyme A) Reductase Inhibitors

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