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A very potent uptake inhibitor highly selective for serotonin (Ki = 3.3 nM). Clinically prescribed as an antidepressant drug. Often used in studying major depressive disorders.
Brunoni, R., et al. 2013. JAMA Psychiatry.70, 383. Kobayashi, K., et al. 1995. Br. J. Clin. Pharmacol.40, 481. Heym, J., et al. 1988. J. Clin. Psychiatry.49 Suppl, 40. Koe, K., et al. 1983. J. Pharmacol. Exp. Ther.226, 700.
Brunoni, R., et al. 2013. JAMA Psychiatry.70, 383. Kobayashi, K., et al. 1995. Br. J. Clin. Pharmacol.40, 481. Heym, J., et al. 1988. J. Clin. Psychiatry.49 Suppl, 40. Koe, K., et al. 1983. J. Pharmacol. Exp. Ther.226, 700.
数据表
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
A very potent uptake inhibitor highly selective for serotonin (Ki = 3.3 nM). Clinically prescribed as an antidepressant drug. Often used in studying major depressive disorders.
Form
White solid
CAS number
79559-97-0
Chemical formula
C₁₇H₁₇Cl₂N•HCl
Structure formula
Purity
≥99% by HPLC
Solubility
DMSO (100 mM) or Ethanol (50 mM)
Storage
Protect from light
+2°C to +8°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Standard Handling
References
Brunoni, R., et al. 2013. JAMA Psychiatry.70, 383. Kobayashi, K., et al. 1995. Br. J. Clin. Pharmacol.40, 481. Heym, J., et al. 1988. J. Clin. Psychiatry.49 Suppl, 40. Koe, K., et al. 1983. J. Pharmacol. Exp. Ther.226, 700.
