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572635 Sigma-AldrichSU6656 - CAS 330161-87-0 - Calbiochem

SU6656, CAS 330161-87-0, is a cell-permeable, potent, reversible, ATP-competitive inhibitor of Src (IC50 = 280 nM). Also inhibits Fyn (IC50 = 170 nM), Yes (IC50 = 20 nM), and Lyn (IC50 = 130 nM).

SU6656 - CAS 330161-87-0 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet
Citations

Primary Target: Src

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
330161-87-0	C₁₉H₂₁N₃O₃S

价格及供货情况

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Description
Overview	A potent, cell-permeable, reversible, and ATP-competitive Src family kinase inhibitor. Inhibits Src (IC₅₀ = 280 nM) as well as closely related kinases such as Fyn (IC₅₀ = 170 nM) and Yes (IC₅₀ = 20 nM) and Lyn (IC₅₀ = 130 nM). Acts as a weak inhibitor of Lck (IC₅₀ = 688 µM) and PDGF receptor kinase (IC₅₀ >10 µM). A 10 mM (500 µg/135 µl) solution of SU6656 (Cat. No. 572636) in DMSO is also available.
Catalogue Number	572635
Brand Family	Calbiochem®

References
References	Bowman, T., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 7319. Blake, R.A., et al. 2000. Mol. Cell. Biol. 20, 9018.

Product Information
CAS number	330161-87-0
ATP Competitive	Y
Form	Burnt orange solid
Hill Formula	C₁₉H₂₁N₃O₃S
Chemical formula	C₁₉H₂₁N₃O₃S
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications
Application	SU6656, CAS 330161-87-0, is a cell-permeable, potent, reversible, ATP-competitive inhibitor of Src (IC50 = 280 nM). Also inhibits Fyn (IC50 = 170 nM), Yes (IC50 = 20 nM), and Lyn (IC50 = 130 nM).

Biological Information
Primary Target	Src
Primary Target IC<sub>50</sub>	280 nM, 170 nM, 20 nM, and 130 nM against Src, Fyn, Yes, and Lyn.
Purity	≥97% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
572635-1MGCN	04055977266290

Documentation

SU6656 - CAS 330161-87-0 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

SU6656 - CAS 330161-87-0 - Calbiochem 分析证书

标题	批号
572635	输入批号

参考

参考信息概述
Bowman, T., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 7319. Blake, R.A., et al. 2000. Mol. Cell. Biol. 20, 9018.

引用

标题

Malcolm A. Meyn, et al. (2005) Src family kinase activity is required for murine embryonic stem cell growth and differentiation. Molecular Pharmacology 68, 1320-1330.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	17-March-2010 JSW
Description	A potent, cell-permeable, reversible, and ATP-competitive inhibitor of Src-family protein tyrosine kinases. Inhibits Src (IC₅₀ = 280 nM) as well as closely related kinases Fyn (IC₅₀ = 170 nM), Yes (IC₅₀ = 20 nM) and Lyn (IC₅₀ = 130 nM). The inhibition is competitive with respect to ATP. Has only a trivial effect on Lck (IC₅₀ = 6.88 µM). Does not affect the activity of PDGF-β receptor kinase (IC₅₀ ≥10 µM) and IGF-1 receptor kinase (IC₅₀ ≥20 µM).
Form	Burnt orange solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	330161-87-0
Chemical formula	C₁₉H₂₁N₃O₃S
Structure formula
Purity	≥97% by HPLC
Solubility	DMSO (25 mg/ml)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Bowman, T., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 7319. Blake, R.A., et al. 2000. Mol. Cell. Biol. 20, 9018.
Citation	Malcolm A. Meyn, et al. (2005) Src family kinase activity is required for murine embryonic stem cell growth and differentiation. Molecular Pharmacology 68, 1320-1330.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Tyrosine Kinase (PTK) Inhibitors

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