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			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

567860 Sigma-AldrichSRT1720 - CAS 925434-55-5 - Calbiochem

SRT1720, CAS 925434-55-5, is a cell-permeable inhibitor of the mitochondrial SIRT3. Inhibition is AceCS2-competitive (Ki = 0.56 µM; Km = 2.44 µM), but NAD+-uncompetitive (Ki = 0.34 µM; Km = 280 µM).

SRT1720 - CAS 925434-55-5 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

分析证书
参考
Data Sheet

同义词: N-(2-(3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)-2-quinolinecarboxamide, Sirtuin-3 Inhibitor, SRT1720, HAT Inhibitor XI, Histone Acetyltransferase Inhibitor XI, p300/CBP Inhibitor IX, SIRT3 Inhibitor II

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
925434-55-5	C₂₅H₂₃N₇O_S

价格及供货情况

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Description
Overview	A cell-permeable quinolinecarboxamide compound that is shown to inhibit the mitochondrial SIRT3 in a substrate AceCS2-competitive (K_i = 0.56 µM; K_m = 2.44 µM), but NAD⁺-uncompetitive (K_i = 0.34 µM; K_m = 280 µM), manner. Also reported to decrease cellular p53 Lys382 acetylation (Effective conc. = 10 µM in U2OS and MEF cultures) and inhibit p300 HAT activity (IC₅₀ = 9 µM) in vitro, as well as offer therapeutic benefits in several murine and rodent type 2 diabetes models (100 mg/kg/dayl p.o.) in vivo. Whether and how SRT1720 activates SIRT1 activity remains uncertain. Also available as a 25 mM solution in DMSO (Cat. No. 530748).
Catalogue Number	567860
Brand Family	Calbiochem®
Synonyms	N-(2-(3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)-2-quinolinecarboxamide, Sirtuin-3 Inhibitor, SRT1720, HAT Inhibitor XI, Histone Acetyltransferase Inhibitor XI, p300/CBP Inhibitor IX, SIRT3 Inhibitor II

References
References	Baur, J.A., et al. 2012. Nat. Rev. Drug Discov. 11, 443. Minor, R.K., et al. 2011. Sci. Rep. 1, 70. Huber, J.L., et al. 2010. Future Med. Chem. 2, 1751 Pacholec, M., et al. 2010. J. Biol. Chem. 285, 8340 Jin, L., et al. 2009. Protein Sci. 18, 514 Feige, J.N., et al. 2008. Cell Metab. 8, 347 Milne, J.C., et al. 2007. Nature 450, 712.

Product Information
CAS number	925434-55-5
Form	Yellow solid
Hill Formula	C₂₅H₂₃N₇O_S
Chemical formula	C₂₅H₂₃N₇O_S
Structure formula Image
Quality Level	MQ100

Applications
Application	SRT1720, CAS 925434-55-5, is a cell-permeable inhibitor of the mitochondrial SIRT3. Inhibition is AceCS2-competitive (Ki = 0.56 µM; Km = 2.44 µM), but NAD+-uncompetitive (Ki = 0.34 µM; Km = 280 µM).

Biological Information
Purity	≥97% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity	Regulatory Review
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
567860-10MGCN	04055977190380

Documentation

SRT1720 - CAS 925434-55-5 - Calbiochem 分析证书

标题	批号
567860	输入批号

参考

参考信息概述
Baur, J.A., et al. 2012. Nat. Rev. Drug Discov. 11, 443. Minor, R.K., et al. 2011. Sci. Rep. 1, 70. Huber, J.L., et al. 2010. Future Med. Chem. 2, 1751 Pacholec, M., et al. 2010. J. Biol. Chem. 285, 8340 Jin, L., et al. 2009. Protein Sci. 18, 514 Feige, J.N., et al. 2008. Cell Metab. 8, 347 Milne, J.C., et al. 2007. Nature 450, 712.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	02-October-2012 JSW
Synonyms	N-(2-(3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)-2-quinolinecarboxamide, Sirtuin-3 Inhibitor, SRT1720, HAT Inhibitor XI, Histone Acetyltransferase Inhibitor XI, p300/CBP Inhibitor IX, SIRT3 Inhibitor II
Description	A cell-permeable quinolinecarboxamide compound that is shown to inhibit the mitochondrial SIRT3 in a substrate AceCS2- (Acetyl-CoA synthetase 2) competitive (K_i = 0.56 µM; K_m = 2.44 µM; V_max = 173.35 µM/min), but NAD⁺-uncompetitive (K_i = 0.34 µM; K_m = 280 µM; V_max = 0.86 µM/min), manner, indicative of NAD⁺ binding as a prerequisite for inhibitor binding. Also reported to decrease cellular p53 Lys382 acetylation (Effective conc. = 10 µM in U2OS and MEF cultures) and inhibit p300 HAT activity (IC₅₀ = 9 µM) in vitro, as well as offer therapeutic benefits in several murine and rodent type 2 diabetes models (100 mg/kg/dayl p.o.) in vivo. Whether and how SRT1720 activates SIRT1 activity remains uncertain.
Form	Yellow solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	925434-55-5
Chemical formula	C₂₅H₂₃N₇O_S
Structure formula
Purity	≥97% by HPLC
Solubility	DMSO (2.5 mg/ml; clear, yellow solution)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Regulatory Review
References	Baur, J.A., et al. 2012. Nat. Rev. Drug Discov. 11, 443. Minor, R.K., et al. 2011. Sci. Rep. 1, 70. Huber, J.L., et al. 2010. Future Med. Chem. 2, 1751 Pacholec, M., et al. 2010. J. Biol. Chem. 285, 8340 Jin, L., et al. 2009. Protein Sci. 18, 514 Feige, J.N., et al. 2008. Cell Metab. 8, 347 Milne, J.C., et al. 2007. Nature 450, 712.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Cell Cycle/Cell Division > Histone Acetylase and Deacetylase Inhibitors

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