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567417 Sigma-AldrichSOD1 Inhibitor, LCS-1 - CAS 41931-13-9 - Calbiochem

The SOD1 Inhibitor, LCS-1, also referenced under CAS 41931-13-9, controls the biological activity of SOD1.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: lung cancer screen 1, 4,5-dichloro-2-m-tolylpyridazin-3(2H)-one, 4,5-dichloro-2-(3-methylphenyl)-3(2H)-pyridazinone, Superoxide dismutase 1 inhibitor

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
41931-13-9	C₁₁H₈Cl₂N₂O

价格及供货情况

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Description
Overview	A 2-phenylpyridazin-3(2H)-one based non-copper chelater that selectively inhibits the activity of Superoxide dismutase 1 (Cu/Zn-SOD) (IC₅₀ = 1.07 µM). Cells over-expressing SOD1 show reduced sensitivity to LCS-1. Shown to preferably inhibit the growth of a variety of human lung adenocarinoma cell lines with EGFR and KRAS mutations (IC₅₀ = 200 nM). Prevents serum-induced activation of the ERK and PI 3-kinase/AKT signaling thereby affecting cell growth and survival. Apparent half-life of this compound is reported to be 6.6 min in human liver microsomes.
Catalogue Number	567417
Brand Family	Calbiochem®
Synonyms	lung cancer screen 1, 4,5-dichloro-2-m-tolylpyridazin-3(2H)-one, 4,5-dichloro-2-(3-methylphenyl)-3(2H)-pyridazinone, Superoxide dismutase 1 inhibitor

References
References	Somwar, R., et al. 2011, PNAS in press. Somwar, R., et al. 2009. J. Biomol. Screen 14, 1176

Product Information
CAS number	41931-13-9
Form	White solid
Hill Formula	C₁₁H₈Cl₂N₂O
Chemical formula	C₁₁H₈Cl₂N₂O
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	≥99% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
567417-10MGCN	04055977267242

Documentation

SOD1 Inhibitor, LCS-1 - CAS 41931-13-9 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

SOD1 Inhibitor, LCS-1 - CAS 41931-13-9 - Calbiochem 分析证书

标题	批号
567417	输入批号

参考

参考信息概述
Somwar, R., et al. 2011, PNAS in press. Somwar, R., et al. 2009. J. Biomol. Screen 14, 1176

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	27-June-2012 JSW
Synonyms	lung cancer screen 1, 4,5-dichloro-2-m-tolylpyridazin-3(2H)-one, 4,5-dichloro-2-(3-methylphenyl)-3(2H)-pyridazinone, Superoxide dismutase 1 inhibitor
Description	A 2-phenylpyridazin-3(2H)-one based non-copper chelater that selectively inhibits the activity of Superoxide dismutase 1 (Cu/Zn-SOD) (IC₅₀ = 1.07 µM). Cells over-expressing SOD1 show reduced sensitivity to LCS-1. Shown to preferably inhibit the growth of a variety of human lung adenocarinoma cell lines with EGFR and KRAS mutations (IC₅₀ = 200 nM). Prevents serum-induced activation of the ERK and PI 3-kinase/AKT signaling thereby affecting cell growth and survival. Apparent half-life of this compound is reported to be 6.6 min in human liver microsomes.
Form	White solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	41931-13-9
Chemical formula	C₁₁H₈Cl₂N₂O
Structure formula
Purity	≥99% by HPLC
Solubility	DMSO (50 mg/mlg; clear, colorless solution)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Somwar, R., et al. 2011, PNAS in press. Somwar, R., et al. 2009. J. Biomol. Screen 14, 1176

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest

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