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567310 SKF-96365, Hydrochloride - CAS 130495-35-1 - Calbiochem

Inhibits receptor-mediated Ca2+ entry in activated platelets, neutrophils, and endothelial cells at concentrations that do not affect internal Ca2+ release.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: 1-[β-[3-(4-Methoxyphenyl)propoxy]-4-methoxyphenethyl]-1H-imidazole, HCl

Primary Target: Inhibits receptor-mediated Ca2+ entry
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567310
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概述

Replacement Information

重要规格表

CAS #Empirical Formula
130495-35-1C₂₂H₂₆N₂O₃ . HCl

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      Description
      OverviewInhibits receptor-mediated Ca2+ entry in activated platelets, neutrophils, and endothelial cells at concentrations that do not affect internal Ca2+ release. Also inhibits voltage-gated Ca2+ entry in excitable cells. Inhibits the histamine-induced formation of nitric oxide in human endothelial cells.
      Catalogue Number567310
      Brand Family Calbiochem®
      Synonyms1-[β-[3-(4-Methoxyphenyl)propoxy]-4-methoxyphenethyl]-1H-imidazole, HCl
      References
      ReferencesLeung, Y.-M., et al. 1996. Biochem. Pharmacol. 51, 605.
      Schwartz, G., et al. 1994. Cell Calcium 15, 45.
      Cabello, O.A. and Schilling, W.P. 1993. Biochem. J. 295, 357.
      Graier, W.F., et al. 1992. Biochem. Biophys. Res. Commun. 186, 1539.
      Blayney, L.M., et al. 1991. Biochem. J. 273, 803.
      Fasolato, C., et al. 1990. J. Biol. Chem. 265, 20351.
      Merritt, J.E., et al. 1990. Biochem. J. 271, 515.
      Product Information
      CAS number130495-35-1
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₂H₂₆N₂O₃ . HCl
      Chemical formulaC₂₂H₂₆N₂O₃ . HCl
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetInhibits receptor-mediated Ca2+ entry
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +15°C to +30°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      产品目录编号 GTIN
      567310-5MGCN 04055977267204

      Documentation

      SKF-96365, Hydrochloride - CAS 130495-35-1 - Calbiochem MSDS

      职位

      物料安全数据表 (MSDS) 

      SKF-96365, Hydrochloride - CAS 130495-35-1 - Calbiochem 分析证书

      标题批号
      567310

      参考

      参考信息概述
      Leung, Y.-M., et al. 1996. Biochem. Pharmacol. 51, 605.
      Schwartz, G., et al. 1994. Cell Calcium 15, 45.
      Cabello, O.A. and Schilling, W.P. 1993. Biochem. J. 295, 357.
      Graier, W.F., et al. 1992. Biochem. Biophys. Res. Commun. 186, 1539.
      Blayney, L.M., et al. 1991. Biochem. J. 273, 803.
      Fasolato, C., et al. 1990. J. Biol. Chem. 265, 20351.
      Merritt, J.E., et al. 1990. Biochem. J. 271, 515.
      数据表

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-October-2019 JSW
      Synonyms1-[β-[3-(4-Methoxyphenyl)propoxy]-4-methoxyphenethyl]-1H-imidazole, HCl
      DescriptionInhibits receptor-mediated Ca2+ entry in stimulated platelets (IC50 = 8-12 µM in intact platelets), neutrophils, and endothelial cells (IC50 = 30 µM for human endothelial cells) at concentrations that do not affect internal Ca2+ release. Also inhibits voltage-gated Ca2+ entry in excitable cells. Inhibits the histamine-induced formation of nitric oxide in human endothelial cells.
      FormWhite solid
      CAS number130495-35-1
      Chemical formulaC₂₂H₂₆N₂O₃ . HCl
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityH₂O (2 mg/ml)
      Storage +15°C to +30°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Irritant
      ReferencesLeung, Y.-M., et al. 1996. Biochem. Pharmacol. 51, 605.
      Schwartz, G., et al. 1994. Cell Calcium 15, 45.
      Cabello, O.A. and Schilling, W.P. 1993. Biochem. J. 295, 357.
      Graier, W.F., et al. 1992. Biochem. Biophys. Res. Commun. 186, 1539.
      Blayney, L.M., et al. 1991. Biochem. J. 273, 803.
      Fasolato, C., et al. 1990. J. Biol. Chem. 265, 20351.
      Merritt, J.E., et al. 1990. Biochem. J. 271, 515.