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565851 SHP1/2 PTPase Inhibitor, NSC-87877 - CAS 56932-43-5 - Calbiochem

SHP1/2 PTPase Inhibitor, NSC-87877, CAS 56932-43-5, is a cell-permeable, potent, catalytic site-targeting inhibitor of SHP-1 and SHP-2 tyrosine phosphatases (IC50 = 355 nM & 318 nM, respectively).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: 8-Hydroxy-7-(6-sulfonaphthalen-2-yl)diazenyl-quinoline-5-sulfonic acid, Disodium Salt, HePTP Inhibitor II, PTP Inhibitor XXV, PTP1B Inhibitor IV, SHP1 Inhibitor I, SHP2 Inhibitor I

Primary Target: SHP1/2 PTPase
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565851
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概述

Replacement Information

重要规格表

CAS #Empirical Formula
56932-43-5C₁₉H₁₁N₃Na₂O₇S₂

价格及供货情况

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565851-50MGCN
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      Description
      OverviewA cell-permeable 7-aza-8-hydroxyquinoline compound that acts as a potent, catalytic site-targeting inhibitor of SHP-1 and SHP-2 protein tyrosine phosphatases (IC50 = 355 nM and 318 nM, respectively). It inhibits PTP1B and HePTP with less potency (IC50 = 1.69 µM and 7.75 µM, respectively) and exhibits >200-fold selectivity over DEP1, CD45, and LAR. Shown to inhibit both basal and stimulated SHP-2 activity in HEK293 cells.
      Catalogue Number565851
      Brand Family Calbiochem®
      Synonyms8-Hydroxy-7-(6-sulfonaphthalen-2-yl)diazenyl-quinoline-5-sulfonic acid, Disodium Salt, HePTP Inhibitor II, PTP Inhibitor XXV, PTP1B Inhibitor IV, SHP1 Inhibitor I, SHP2 Inhibitor I
      References
      ReferencesChen, L., et al. 2006. Mol. Pharmacol. 70, 562.
      Product Information
      CAS number56932-43-5
      ATP CompetitiveN
      FormRedish brown solid
      Hill FormulaC₁₉H₁₁N₃Na₂O₇S₂
      Chemical formulaC₁₉H₁₁N₃Na₂O₇S₂
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationSHP1/2 PTPase Inhibitor, NSC-87877, CAS 56932-43-5, is a cell-permeable, potent, catalytic site-targeting inhibitor of SHP-1 and SHP-2 tyrosine phosphatases (IC50 = 355 nM & 318 nM, respectively).
      Biological Information
      Primary TargetSHP1/2 PTPase
      Primary Target IC<sub>50</sub>355 nM and 318 nM against SHP-1 and SHP-2 protein tyrosine phosphatases, respectively
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      产品目录编号 GTIN
      565851-50MGCN 04055977191271

      Documentation

      SHP1/2 PTPase Inhibitor, NSC-87877 - CAS 56932-43-5 - Calbiochem MSDS

      职位

      物料安全数据表 (MSDS) 

      SHP1/2 PTPase Inhibitor, NSC-87877 - CAS 56932-43-5 - Calbiochem 分析证书

      标题批号
      565851

      参考

      参考信息概述
      Chen, L., et al. 2006. Mol. Pharmacol. 70, 562.

      小册子

      标题
      An Introduction to Inhibitors and Their Biological Applications - 1st Edition
      数据表

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision10-September-2008 RFH
      Synonyms8-Hydroxy-7-(6-sulfonaphthalen-2-yl)diazenyl-quinoline-5-sulfonic acid, Disodium Salt, HePTP Inhibitor II, PTP Inhibitor XXV, PTP1B Inhibitor IV, SHP1 Inhibitor I, SHP2 Inhibitor I
      DescriptionA cell-permeable 7-aza-8-hydroxyquinoline compound that acts as a potent, catalytic site-targeting inhibitor of SHP-1 and SHP-2 protein tyrosine phosphatases (IC50 = 355 nM and 318 nM, respectively). It inhibits PTP1B and HePTP with less potency (IC50 = 1.69 µM and 7.75 µM, respectively) and exhibits >200-fold selectivity over DEP1, CD45, and LAR. Shown to inhibit both basal and stimulated SHP-2 activity in HEK293 cells.
      FormRedish brown solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number56932-43-5
      Chemical formulaC₁₉H₁₁N₃Na₂O₇S₂
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityH₂O (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesChen, L., et al. 2006. Mol. Pharmacol. 70, 562.