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559418 Sigma-AldrichSBHA - CAS 38937-66-5 - Calbiochem

A cell-permeable bishydroxamic acid histone deacetylase (HDAC) inhibitor with anti-tumor properties.

SBHA - CAS 38937-66-5 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

分析证书
参考
技术信息
Data Sheet

同义词: Suberic Bishydroxamate, Suberoyl Bishydroxamic Acid, HDAC Inhibitor XII

Primary Target: human HDAC1 and HDAC3 activities

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
38937-66-5	C₈H₁₆N₂O₄

价格及供货情况

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Description
Overview	A cell-permeable bishydroxamic acid histone deacetylase (HDAC) inhibitor with anti-tumor properties. Causes an increase in acetylated histone H4 in MEL cells and inhibits the human HDAC1 and HDAC3 activities with a similar potency (ID₅₀ ~ 250-300 nM). Belongs to the hybrid polar class of compounds that acts both as inducers of differentiation of transformed cells and apoptosis. Suppresses the growth of proliferating keratinocytes and squamous cell carcinoma cells (IC₅₀ = 11.57 µM and 5.39 µM, respectively).
Catalogue Number	559418
Brand Family	Calbiochem®
Synonyms	Suberic Bishydroxamate, Suberoyl Bishydroxamic Acid, HDAC Inhibitor XII

References
References	Brinkmann, H., et al. 2001. J. Biol. Chem. 276, 22491. Richon, V.M., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 3003. Richon, V.M., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 5705. Marks, P.A., 1994. Proc. Natl. Acad. Sci. USA 91, 10251.

Product Information
CAS number	38937-66-5
ATP Competitive	N
Declaration	Not available for sale in the United States.
Form	White solid
Hill Formula	C₈H₁₆N₂O₄
Chemical formula	C₈H₁₆N₂O₄
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	human HDAC1 and HDAC3 activities
Primary Target IC<sub>50</sub>	11.57 µM and 5.39 µM in suppressing the growth of proliferating keratinocytes and squamous cell carcinoma cells, respectively
Purity	≥95% by TLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. From Catalog: Desc. Field- added "cell-permeable

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
559418-100MGCN	04055977268171

Documentation

SBHA - CAS 38937-66-5 - Calbiochem 分析证书

标题	批号
559418	输入批号

参考

参考信息概述
Brinkmann, H., et al. 2001. J. Biol. Chem. 276, 22491. Richon, V.M., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 3003. Richon, V.M., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 5705. Marks, P.A., 1994. Proc. Natl. Acad. Sci. USA 91, 10251.

技术信息

标题
White Paper - The Message in the Marks: Deciphering Cancer Epigenetics

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	20-September-2021 JSW
Synonyms	Suberic Bishydroxamate, Suberoyl Bishydroxamic Acid, HDAC Inhibitor XII
Description	A cell-permeable bishydroxamic acid histone deacetylase (HDAC) inhibitor with anti-tumor properties. Reported to cause an increase in acetylated histone H4 in MEL cells. Also reported to inhibit human HDAC1 and HDAC3 activities with a similar potency (ID₅₀ ~ 250-300 nM). Belongs to the hybrid polar class of compounds that induce both differentiation of transformed cells and apoptosis. Shown to suppress the growth of proliferating keratinocytes and squamous cell carcinoma cells (IC₅₀ = 11.57 µM and 5.39 µM, respectively).
Form	White solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	38937-66-5
Chemical formula	C₈H₁₆N₂O₄
Structure formula
Purity	≥95% by TLC
Solubility	DMSO (10 mg/ml)
Storage	+2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. From Catalog: Desc. Field- added "cell-permeable
Toxicity	Standard Handling
References	Brinkmann, H., et al. 2001. J. Biol. Chem. 276, 22491. Richon, V.M., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 3003. Richon, V.M., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 5705. Marks, P.A., 1994. Proc. Natl. Acad. Sci. USA 91, 10251.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Cell Cycle/Cell Division > Histone Acetylase and Deacetylase Inhibitors

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