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			96-Well Plate

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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

559405 Sigma-AldrichSB 225002 - CAS 182498-32-4 - Calbiochem

A potent, selective, and competitive antagonist of the G-protein coupled receptor CXCR2 (IL-8RB; IC₅₀ = 22 nM for the inhibition of ¹²⁵I-IL-8 binding to CXCR2).

SB 225002 - CAS 182498-32-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: N-(2-Hydroxy-4-nitrophenyl)-Nʹ-(2-bromophenyl)urea, CXCR2 Antagonist II

Primary Target: CXCR2

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
182498-32-4	C₁₃H₁₀BrN₃O₄

价格及供货情况

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Description
Overview	A potent, selective, and competitive antagonist of the G-protein coupled receptor CXCR2 (IL-8RB; IC₅₀ = 22 nM for the inhibition of ¹²⁵I-IL-8 binding to CXCR2). Shows ~150-fold selectivity over CXCR1. Inhibits human and rabbit neutrophil chemotaxis induced by both IL-8 and GROα in vitro and in vivo selectively blocks IL-8-induced neutrophil margination in rabbits. Reduces presenilin expression, inhibits γ-secretase activity, and blocks Aβ40/42 production and notch processing; further, demonstrates in vivo efficacy in mouse models.
Catalogue Number	559405
Brand Family	Calbiochem®
Synonyms	N-(2-Hydroxy-4-nitrophenyl)-Nʹ-(2-bromophenyl)urea, CXCR2 Antagonist II

References
References	Bakshi, P., et al. 2009. ACS Chem. Biol. in press. White, J.R., et al. 1998. J. Biol. Chem. 273, 10095.

Product Information
CAS number	182498-32-4
ATP Competitive	N
Form	Yellow solid
Hill Formula	C₁₃H₁₀BrN₃O₄
Chemical formula	C₁₃H₁₀BrN₃O₄
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	CXCR2
Primary Target IC<sub>50</sub>	22 nM for the inhibition of 125I-IL-8 binding to CXCR2
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	N

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
559405-1MGCN	04055977191967

Documentation

SB 225002 - CAS 182498-32-4 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

SB 225002 - CAS 182498-32-4 - Calbiochem 分析证书

标题	批号
559405	输入批号

参考

参考信息概述
Bakshi, P., et al. 2009. ACS Chem. Biol. in press. White, J.R., et al. 1998. J. Biol. Chem. 273, 10095.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	19-April-2011 RFH
Synonyms	N-(2-Hydroxy-4-nitrophenyl)-Nʹ-(2-bromophenyl)urea, CXCR2 Antagonist II
Description	A potent and selective antagonist of G-protein coupled receptor CXCR2 (IL-8RB; IC₅₀ = 22 nM for the inhibition of ¹²⁵I-IL-8 binding to CXCR2). Inhibits human and rabbit neutrophil chemotaxis induced by both IL-8 and GROα in vitro and selectively blocks IL-8-induced neutrophil margination in rabbits. Reduces presenilin expression, inhibits γ-secretase activity, and blocks Aβ40/42 production and notch processing; further, demonstrates in vivo efficacy in mouse models.
Form	Yellow solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	182498-32-4
Chemical formula	C₁₃H₁₀BrN₃O₄
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (200 mg/ml)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Bakshi, P., et al. 2009. ACS Chem. Biol. in press. White, J.R., et al. 1998. J. Biol. Chem. 273, 10095.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Neurobiology / Neurodegeneration > Secretase Inhibitors

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