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A selective 5-HT2C serotonin receptor inhibitor with lesser affinity for 5-HT2BR. Often used in conjunction with ketanserin to distinguish 5-HT2AR and 5-HT2CR activity. SB206553 has highest affinity for 5-HT2CR (Ki = 3.2nM) and less for 5-HT2BR (Ki = 5.5 nM) and 5-HT2AR (Ki = 2,300 nM).
Ros, R. et al. 2013. PNAS.110, 348. Knight, A. R. et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol.370, 114. Cussac, D. et al. 2002. Naunyn Schmiedebergs Arch. Pharmacol.365, 242.
Ros, R. et al. 2013. PNAS.110, 348. Knight, A. R. et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol.370, 114. Cussac, D. et al. 2002. Naunyn Schmiedebergs Arch. Pharmacol.365, 242.
数据表
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
A selective 5-HT2C serotonin receptor inhibitor with lesser affinity for 5-HT2BR. Often used in conjunction with ketanserin to distinguish 5-HT2AR and 5-HT2CR activity. SB206553 has highest affinity for 5-HT2CR (Ki = 3.2nM) and less for 5-HT2BR (Ki = 5.5 nM) and 5-HT2AR (Ki = 2,300 nM).
Form
Yellow solid
CAS number
158942-04-2
Chemical formula
C₁₇H₁₆N₄O·HCl
Structure formula
Purity
≥99% by HPLC
Solubility
DMSO
Storage
Protect from light
+2°C to +8°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Standard Handling
References
Ros, R. et al. 2013. PNAS.110, 348. Knight, A. R. et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol.370, 114. Cussac, D. et al. 2002. Naunyn Schmiedebergs Arch. Pharmacol.365, 242.
