Millipore Sigma Vibrant Logo

559389 SB 203580 - CAS 152121-47-6 - Calbiochem

SB 203580, CAS 152121-47-6, is a highly specific, potent, cell-permeable, selective, reversible, and ATP-competitive inhibitor of p38 MAP kinase (IC₅₀ = 34 nM in vitro, 600 nM in cells).

SB 203580 - CAS 152121-47-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole, p38 MAP Kinase Inhibitor XVI

Primary Target: P38MAPK
View Products on Sigmaaldrich.com
559389
查看价格及供货情况

概述

重要规格表

CAS #Empirical Formula
152121-47-6C₂₁H₁₆N₃OSF

价格及供货情况

产品目录编号 库存情况包装 数量 / 包装 价格 数量
559389-10MGCN
—
目前缺货 目前缺货
有货 
停产
少量现货
供货情况有待确认
    其余：另行通知
      其余：另行通知
      另行通知
      联系客户服务
      Contact Customer Service

      		 玻璃瓶 10 mg
      无法检索价格。
      最小订购数量为倍数
      Maximum Quantity is
      以订单确认为准 更多信息
      您节约了 ()。
       
      —
      Request Pricing
      		 —
      添加到收藏夹
      559389-1MGCN
      —
      目前缺货 目前缺货
      有货 
      停产
      少量现货
      供货情况有待确认
        其余：另行通知
          其余：另行通知
          另行通知
          联系客户服务
          Contact Customer Service

          		 塑胶安瓿;塑胶针药瓶 1 mg
          无法检索价格。
          最小订购数量为倍数
          Maximum Quantity is
          以订单确认为准 更多信息
          您节约了 ()。
           
          —
          Request Pricing
          		 —
          添加到收藏夹
          559389-5MGCN
          —
          目前缺货 目前缺货
          有货 
          停产
          少量现货
          供货情况有待确认
            其余：另行通知
              其余：另行通知
              另行通知
              联系客户服务
              Contact Customer Service

              		 玻璃瓶 5 mg
              无法检索价格。
              最小订购数量为倍数
              Maximum Quantity is
              以订单确认为准 更多信息
              您节约了 ()。
               
              —
              Request Pricing
              		 —
              添加到收藏夹
              Description
              OverviewReduces epirubicin-induced cell injury and caspase-3/7 activity. A highly specific, potent, cell-permeable, selective, reversible, and ATP-competitive inhibitor of p38 MAP kinase (IC50 = 34 nM in vitro, 600 nM in cells). Does not significantly inhibit the JNK and p42 MAP kinase at 100 µM. Inhibits IL-1 and TNF-α production from LPS-stimulated human monocytes and the human monocyte cell line THP-1 (IC50 = 50-100 nM). Inhibits bone morphogenetic protein-2-induced neurite outgrowth in PC12 cells. Also inhibits platelet aggregation caused by collagen (IC50 = 0.2-1.0 µM) or the thromboxane analog U-46619 (Cat. No. 538944). A 1 mg/ml solution of SB 203580 (Cat. No. 559398) in anhydrous DMSO is also available.
              Catalogue Number559389
              Brand Family Calbiochem®
              Synonyms4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole, p38 MAP Kinase Inhibitor XVI
              References
              ReferencesYamada. T., et al. 2012. Free Radic. Biol. Med. (In press)
              Powell, D.J., et al. 2003. Mol. Cell Biol. 23, 7794.
              Davies, S.P., et al. 2000. Biochem. J. 351, 95.
              Iwasaki, S., et al. 1999. J. Biol. Chem. 274, 26503.
              Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49.
              LoGrasso, P.V., et al. 1997. Biochem. 36, 10422.
              Hazzalin, C.A., et al. 1996. Curr. Biol. 6, 1028.
              Kramer, R.M., et al. 1996. J. Biol. Chem. 271, 27723.
              Saklatvala, J., et al. 1996. J. Biol. Chem. 271, 6586.
              Cuenda, A., et al. 1995. FEBS Lett. 364, 229.
              Gallagher, T.F., et al. 1995. Bioorg. Med. Chem. Lett. 5, 1171.
              Lee, J.C., et al. 1994. Nature 372, 739.
              Product Information
              CAS number152121-47-6
              ATP CompetitiveY
              FormThin film
              Hill FormulaC₂₁H₁₆N₃OSF
              Chemical formulaC₂₁H₁₆N₃OSF
              ReversibleY
              Structure formula ImageStructure formula Image
              Quality LevelMQ100
              Applications
              ApplicationSB 203580, CAS 152121-47-6, is a highly specific, potent, cell-permeable, selective, reversible, and ATP-competitive inhibitor of p38 MAP kinase (IC₅₀ = 34 nM in vitro, 600 nM in cells).
              Biological Information
              Primary TargetP38MAPK
              Primary Target IC<sub>50</sub>34 nM against p38 MAP kinase in vitro, 600 nM in cells; 50-100 nM against IL-1 and TNF-α production from LPS-stimulated human monocytes and the human monocyte cell line THP-1; 0.2-1.0 µM against platelet aggregation caused by collagen
              Purity≥98% by HPLC
              Physicochemical Information
              Cell permeableY
              Safety Information
              R PhraseR: 36/37/38

              Irritating to eyes, respiratory system and skin.
              S PhraseS: 26-36-45

              In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
              Wear suitable protective clothing.
              In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Irritant
              Storage -20°C
              Protect from Light Protect from light
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
              Global Trade Item Number
              产品目录编号 GTIN
              559389-10MGCN 04055977192490
              559389-1MGCN 07790788051532
              559389-5MGCN 04055977192537