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557370 Sigma-AldrichRottlerin - CAS 82-08-6 - Calbiochem

Rottlerin, CAS 82-08-6, is a cell-permeable, reversible inhibitor of protein kinase C with greater selectivity for PKCδ (IC50 = 3-6 µM) & PKCθ. Has about 10-fold lower potency against other isozymes.

Rottlerin - CAS 82-08-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet
Citations

同义词: Mallotoxin

Primary Target: PKCδ

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
82-08-6	C₃₀H₂₈O₈

价格及供货情况

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Description
Overview	A cell-permeable and reversible protein kinase C inhibitor that exhibits greater selectivity for PKC_δ (IC₅₀ = 3-6 µM) and PKC_θ. Inhibits the PKC_α, PKC_β, and PKC_γ isoforms, but with significantly reduced potency (IC₅₀ = 30-42 µM). Has reduced inhibitory activity on PKC_ε, PKC_η, and PKC_ζ (IC₅₀ = 80-100 µM). Also known to inhibit CaM kinase III (IC₅₀ = 5.3 µM).
Catalogue Number	557370
Brand Family	Calbiochem®
Synonyms	Mallotoxin

References
References	Villalba, M., et al. 1999. J. Immunol. 163, 5813. Gschwendt, M., et al. 1994. Biochem. Biophys. Res. Commun. 199, 93. Gschwendt, M., et al. 1994. FEBS Lett. 338, 85. Gschwendt, M., et al. 1984. Cancer Lett. 25, 177.

Product Information
CAS number	82-08-6
ATP Competitive	N
Form	Orange solid
Hill Formula	C₃₀H₂₈O₈
Chemical formula	C₃₀H₂₈O₈
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications
Application	Rottlerin, CAS 82-08-6, is a cell-permeable, reversible inhibitor of protein kinase C with greater selectivity for PKCδ (IC50 = 3-6 µM) & PKCθ. Has about 10-fold lower potency against other isozymes.

Biological Information
Primary Target	PKCδ
Primary Target IC<sub>50</sub>	3-6 µM against PKCδ; 5.3 µM against CaM kinase III
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	AM6913800

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+2°C to +8°C
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
557370-10MGCN	04055977268041

Documentation

Rottlerin - CAS 82-08-6 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Rottlerin - CAS 82-08-6 - Calbiochem 分析证书

标题	批号
557370	输入批号

参考

参考信息概述
Villalba, M., et al. 1999. J. Immunol. 163, 5813. Gschwendt, M., et al. 1994. Biochem. Biophys. Res. Commun. 199, 93. Gschwendt, M., et al. 1994. FEBS Lett. 338, 85. Gschwendt, M., et al. 1984. Cancer Lett. 25, 177.

引用

标题

Phuong Thi Nguyen Sarkis, et al. (2006) STAT1-independent cell type-specific regulation of antiviral APOBEC3G by IFN-α. Journal of Immunology 177, 4530-4540.

Ying Zhang, Mingjuan Liao and Maria L. Dufau. (2006) Phosphatidylinositol 3-kinase/protein kinase Cγ-induced phosphorylation of Sp1 and p107 repressor release have a critical role in histone deacetylase inhibitor-mediated depression of transcription of the luteinizing hormone receptor gene. Molecular and Cellular Biology 26, 6748-6761.

Yoon-Jin Lee, et al. (2005) HSP25 inhibits protein kinase Cγ-mediated cell death through direct interaction. Journal of Biological Chemistry 280, 18108-18119.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	11-January-2010 RFH
Synonyms	Mallotoxin
Description	A cell-permeable and reversible inhibitor of protein kinase C δ (PKCδ, IC₅₀ = 3-6 µM) and PKC_Θ isozymes. Also inhibits PKC_α, PKC_β, and PKC_γ isoforms, but with significantly reduced potency (IC₅₀ = 30-42 µM). Has reduced inhibitory activity on PKC_ε, PKC_η, and PKC_ξ (IC₅₀ = 80-100 µM). Also known to inhibit CaM kinase III (IC₅₀ = 5.3 µM).
Form	Orange solid
CAS number	82-08-6
RTECS	AM6913800
Chemical formula	C₃₀H₂₈O₈
Structure formula
Purity	≥98% by HPLC
Solubility	DMSO (30 mg/ml) or Ethanol (1 mg/ml)
Storage	+2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
Merck USA index	14, 8272
References	Villalba, M., et al. 1999. J. Immunol. 163, 5813. Gschwendt, M., et al. 1994. Biochem. Biophys. Res. Commun. 199, 93. Gschwendt, M., et al. 1994. FEBS Lett. 338, 85. Gschwendt, M., et al. 1984. Cancer Lett. 25, 177.
Citation	Phuong Thi Nguyen Sarkis, et al. (2006) STAT1-independent cell type-specific regulation of antiviral APOBEC3G by IFN-α. Journal of Immunology 177, 4530-4540. Ying Zhang, Mingjuan Liao and Maria L. Dufau. (2006) Phosphatidylinositol 3-kinase/protein kinase Cγ-induced phosphorylation of Sp1 and p107 repressor release have a critical role in histone deacetylase inhibitor-mediated depression of transcription of the luteinizing hormone receptor gene. Molecular and Cellular Biology 26, 6748-6761. Yoon-Jin Lee, et al. (2005) HSP25 inhibits protein kinase Cγ-mediated cell death through direct interaction. Journal of Biological Chemistry 280, 18108-18119.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase C (PKC) Inhibitors

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